OBJECTIVES A recent trial showed the clinical benefit of retreatment with varenicline in subjects failing on the initial treatment, or relapsing after initial success. The objective of this study was to evaluate the cost-effectiveness of retreatment with varenicline compared with other smoking cessation interventions. METHODS A published Markov model was adapted to compare one quit attempt of...

BACKGROUND Maternal smoking is associated with disturbed cardiorespiratory control in the infant. Despite lacking knowledge of whether the harmful effects of smoking are caused by combustion products in tobacco smoke or by nicotine, it has been argued that nicotine-replacement therapy during pregnancy is safer than smoking. OBJECTIVE The goal of this study was to investigate if the disturbanc...

Intervention: an intensive smoking cessation intervention plus usual care (n = 109) or usual care only (n = 100). The intensive intervention included weekly 60 minute counselling sessions for >3 months after discharge and individualised nicotine replacement therapy and/or bupropion at no cost. Intervention group patients were re-treated if they started smoking again. Usual care included written...

AIMS To determine the incremental cost effectiveness of nicotine replacement therapy (NRT), bupropion and varenicline for preventing relapse to smoking when used by abstinent smokers DESIGN SETTING AND PARTICIPANTS Cohort simulation and sensitivity analyses combining cost and health service data with systematic review estimates for the effectiveness of NRT, bupropion and varenicline when used...