The roles of actin-binding proteins in development and morphogenesis are not well understood. The actin-binding protein UNC-115 has been implicated in cytoskeletal signaling downstream of Rac in Caenorhabditis elegans axon pathfinding, but the cellular role of UNC-115 in this process remains undefined. Here we report that UNC-115 overactivity in C. elegans neurons promotes the formation of neur...

JERRY SWAN1, GABRIELA OCHOA1, GRAHAM KENDALL1, MARTIN EDJVET2 1Automated Scheduling, Optimisation and Planning (ASAP) Research Group, School of Computer Science and Information Technology, University of Nottingham, Jubilee Campus, Wollaton Road, Nottingham NG8 1BB, UK. Tel.: (+44) (0)115 846 6504, Fax: +44 (0)115 846 7877. 2School of Mathematical Sciences, University of Nottingham, University P...

Shionogi Carcinoma 115 cells (SC 115 cells) and Chiba Subline 2 cells (CS 2 cells) are clones of an androgen-responsive mouse tumor cell line and its autonomous subline, respectively. Since it was reported that the growth of cells from SC 115 was regulated by an androgen-induced fibroblast growth factor (FGF)-like peptide (1), the present study was aimed at examining whether a similar growth fa...

Rac GTPases control cell shape by regulating downstream effectors that influence the actin cytoskeleton. UNC-115, a putative actin-binding protein similar to human abLIM/limatin, has previously been implicated in axon pathfinding. We have discovered the role of UNC-115 as a downstream cytoskeletal effector of Rac signaling in axon pathfinding. We show that unc-115 double mutants with ced-10 Rac...

In the current scenario, machinability of super alloys is greater importance in an aircraft turbine engine and land-based applications owing to its superior properties. However, these found be poor inherent Hence, a predictive model has been developed based on DEFORM 3D forecast machining attributes such as cutting force insert's edge temperature turning Nimonic C263 alloy. The dry trials mater...

Nickel-based superalloys are widely used in the aerospace, automotive, marine and medical sectors, owing to their high mechanical strength corrosion resistance. However, they exhibit poor machinability due low thermal conductivity, shear modulus, strain hardening, etc. Various modifications have been incorporated into existing machining techniques address these issues. One such modification is ...