Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands Erfocentrum, Amersfoort, the Netherlands Department of Obstetrics and Gynaecology, Leiden University Medical Center, Leiden, the Netherlands Department of Obstetrics and Gynaecology, VU University Medical C...

Non-invasive prenatal testing (NIPT) of fetal aneuploidy using cell-free fetal (cffDNA) from mother’s blood sample has shown to be an accurate and reliable screening tool. The current NIPT protocols are based on targeted or whole genome sequencing, which demand resourceintensive bioinformatical capacity. The complexity of current NIPT technology is trustworthy but the comprehensive adaption of ...

Introduction: Non-invasive prenatal testing (NIPT) allows for genetic of a fetus through the analysis cell-free DNA from mother’s plasma. NIPT is easy and safe fetus, since it only requires blood draw mother therefore holds no risk miscarriage. It considered superior to other screening tests can also be performed earlier in pregnancy. has future potential fetal whole genome sequencing (FWGS) an...

A novel and ultrasensitive sandwich-type electrochemical immunosensor was designed for the quantitative detection of carcino-embryonic antigen (CEA). This immunosensor was developed by using the trimetallic NiAuPt nanoparticles on graphene nanosheets (NGs) nanosheets (NiAuPt-NGs) as excellent labels and β-cyclodextrin functionalized reduced graphene oxide nanosheets (CD-NGs) as the platform. Th...

The spin anomalous Hall effect (SAHE) in ferromagnetic metals, which can generate a spin-orbit torque to rotate the magnetization of another layer through nonmagnetic spacer magnetic junctions, has attracted much attention. We theoretically investigated conductivity (SAHC) $L{1}_{0}$-type alloys $X\mathrm{Pt}$ ($X=\mathrm{Fe},\mathrm{Co},\mathrm{Ni}$) on basis first-principles density functiona...

BACKGROUND Discovery of cell-free fetal DNA (cffDNA) in maternal blood in 1997 by Lo et al. has opened the possibility of a noninvasive prenatal test (NIPT). Currently, it is employed in the analysis of aneuploidies and fetal sex determination. Massive parallel sequencing (MPS) detects the origin of each amplified sequence, and analyses over-representation of sequences or any decrease in the fe...