A method was developed for simultaneous qualitative and quantitative analysis of five metabolites of nitrofuran antibiotics, including 3-amino-2-oxazolidinone (AOZ), 5-morpholino-methyl-3-amino-2-oxazolidinone ( AMOZ ), semicarbazide ( SEM ), 1-aminohydantoin (AHD) and 3, 5-dinitrosalicylic acid hydrazide (DNSH) in aquatic products by liquid chromatography-tandem mass spectrometry (LC-MS/MS). T...

Nitrofurazone (NTFZ), a nitrofuran antibiotic, was evaluated for reproductive toxicity in Swiss CD-1 mice using the Reproductive Assessment by Continuous Breeding protocol. Male and female mice were cohabited for 15 weeks and exposed to NTFZ in feed at concentrations of 0, 100, 375, and 750 ppm (14-102 mg/kg/day). Fzero 750-ppm breeding pairs had significantly reduced fertility after 7 days of ...

sources, it is important that relevant models of human liver toxicosis are used in order to identify agents with therapeutic potential. Thus, we considered the use of hepatotoxic agents relevant to human liver toxicosis in assay protocols. Examples of such hepatotoxic agents include pharmaceutical agents like tacrine and nitrofurantoin. Tacrine (1,2,3,4tetrahydro-9-aminoacridine hydrochloride) ...

Nifurtimox, is a nitrofuran compound with a trypanocidal effect against both trypomastigote and amastigote forms of T. cruzi. Its antiparasitic activity is due to the formation of toxic derivatives of oxygen when nifurtimox is reduced. T. cruzi presents low levels of reduced glutathione and lacks catalase and glutathione peroxi-dase, which makes the parasite very sensitive to hydrogen perox-ide...

Furazolidone (FZD), a synthetic nitrofuran derivative, has been widely used as an antibacterial and antiprotozoal agent. Recently, the potential toxicity of FZD has raised concerns, but its mechanism is still unclear. This study aimed to investigate the protective effect of curcumin on FZD induced cytotoxicity and the underlying mechanism in human hepatocyte L02 cells. The results showed that c...

25 It is >25 years since it was first reported that nifurtimox and benznidazole 26 promote superoxide production in trypanosomes. However, there has been no 27 direct evidence of an association between the drug-induced free radicals and 28 trypanocidal activity. Here, we identify a superoxide dismutase required to 29 protect Trypanosoma brucei from drug-generated superoxide. 30 31 32 33 Parasit...

positive Lyme disease serology in human granulocytic ehrlichiosis. Corynebacterium pseudogenitalium Urinary Tract Infection To the Editor: A 64-year-old man was admitted to the urology department of Cochin Hospital in Paris, France, for acute urinary retention. He had a history of recurrent urolithiasis and undocumented urinary tract symptoms. At admission, a urethral catheter was inserted, and...

Background. The aim of this study was to compare the efficacy and safety of long-term use of fosfomycin and nitrofurantoin in the treatment of recurrent uncomplicated lower urinary tract infections (uUTIs) in type 2 diabetic women. Materials and methods. The study included type 2 diabetic women, aged 50–70 years old, suffering from uUTIs and presenting with dysuric symptoms and positive urine c...