As many substances are poorly soluble in water and thus possess decreased bioavailability, creating orally administered forms of these substances is a challenge. The objective of this study was to determine whether the solubility of megestrol acetate, a Biopharmaceutical Classification System (BCS) class II drug, can be improved by using a newly-synthesized surfactant (Rofam 70: a rapeseed meth...

The solubility, pH, electrical conductivity, and radiopacity of AH Plus and MTA FillApex were evaluated. In addition, the surfaces morphologies of the sealers were analyzed by using scanning electron microscopy. For pH test, the samples were immersed in distilled water at different periods of time. The same solution was used for electrical conductivity measurement. The solubility and radiopacit...

cottonseed is considered among most important crops. it contains about 26 percent oil that ‎in used for vegetable oil production. after oil extraction, the remaining part of the seed know as ‎cottonseed cake with 45 percent protein is routinely used as a protein supplement in feed ‎rations for livestock and less for food use due to presence of gossypol, a toxic constituent of ‎cottonseed.‎ in t...

Background This study compared the solubility and the pH of different root canal sealers in vitro. Material and Methods BioRoot™RCS, TotalFill BC Sealer, MTA Fillapex, SealapexTM, AH Plus, EasySeal, Pulp Canal Sealer™ and N2 were tested. Similar specimens were prepared using ring molds with an internal diameter of 20 ± 0,1 mm and a height of 1,5 ± 0,1 mm and digitally weighted to register the...

Satranidazole, a potent broad spectrum antiprotozoal, is a poorly water-soluble drug and has low bioavailability on oral administration. One of the important methods to improve the solubility and bioavailability of a less water-soluble drug is by the use of cosolvents. The solubility enhancement produced by binary blends with a cosolvent (dioxane) was studied against the solubility parameter of...

Solid dispersions (SDs) are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. This technology is mainly applied to improve the solubility of Class II and Class IV drugs. Cefpodoxime proxetil (CP) is chosen as drug as it belongs to Class IV i. e. having low solubility and low permeability (Solubility: 400 μg/ml). SDs were prepared by using PV...

[1] We present results from transient sensitivity studies with the Biogeochemical Elemental Cycling (BEC) ocean model to increasing anthropogenic atmospheric inorganic nitrogen (N) and soluble iron (Fe) deposition over the industrial era. Elevated N deposition results from fossil fuel combustion and agriculture, and elevated soluble Fe deposition results from increased atmospheric processing in...