Various derivatives of adenosine were prepared by acylation of adenosine (6-amino-9-(bD-ribofuranosyl)purine (1) with different molar equivalents of acetic anhydride and/or pivaloyl chloride in pyridine. Compounds 6-acetylamino-9-[(2,3,5-tri-O-acetyl)-b-Dribofuranosyl]purine (3), 6-amino-9-[(2,3,5-tri-O-acetyl)-b-D-ribofuranosyl]purine (4), and 6-pivaloylamino-9-[(2,3,5-tri-O-pivaloyl)-b-D-ribo...

BACKGROUND The nicotine metabolite ratio (NMR or 3-hydroxycotinine/cotinine) has been used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze (i) the stability of NMR in plasma, saliva, and blood in various storage conditions, (ii) the relationship between NMRs derived from blood, plasma, saliva, and urine, and (iii) the reproducibility of plasma NMR in ad libitum ...

As methods for analysis of biomolecular structure and dynamics using nuclear magnetic resonance spectroscopy (NMR) continue to advance, the resulting 3D structures, chemical shifts, and other NMR data are broadly impacting biology, chemistry, and medicine. Structure model assessment is a critical area of NMR methods development, and is an essential component of the process of making these struc...

Nuclear magnetic resonance (NMR) is a physical phenomenon based upon the quantum mechanical magnetic properties of an atoms nucleus. Thereby NMR spectroscopy is a technique to obtain physical, chemical and structural information about molecules. Recent research is focused on the analysis of small molecules, e.g. metabolites by NMR or in a combination of NMR and electro spray ionization mass spe...

Naked mole rat (NMR) is a valuable model for aging and cancer research due to its exceptional longevity and cancer resistance. We observed that the reprogramming efficiency of NMR fibroblasts in response to OSKM was drastically lower than that of mouse fibroblasts. Expression of SV40 LargeT antigen (LT) dramatically improved reprogramming of NMR fibroblasts. Inactivation of Rb alone, but not p5...

Nuclear Magnetic Resonance (NMR) is widely used in medical diagnostics and chemical analysis. Due to rapid growing of the NMR applications, the conventional NMR systems may not fulfill the need of all applications. The development of a micro-NMR device would not only benefit the original NMR applications but could also open a door for new NMR applications. Two approaches for building a NMR syst...

A variety of nuclear magnetic resonance (NMR) applications have been developed for structure-based drug discovery (SBDD). NMR provides many advantages over other methods, such as the ability to directly observe chemical compounds and target biomolecules, and to be used for ligand-based and protein-based approaches. NMR can also provide important information about the interactions in a protein-l...

Nuclear magnetic resonance or NMR is one of the most widely used discoveries of Modern Physics. NMR is based on the bulk magnetic properties of materials made up of certain isotopes, most notably, protons (1H), but encompassing a wide variety of species including C, F, and Si. NMR is used to measure magnetic fields with exquisite precision. NMR is used in chemical analysis, oil exploration, and...

ADAPT-NMR (Assignment-directed Data collection Algorithm utilizing a Probabilistic Toolkit in NMR) represents a groundbreaking prototype for automated protein structure determination by nuclear magnetic resonance (NMR) spectroscopy. With a [(13)C,(15)N]-labeled protein sample loaded into the NMR spectrometer, ADAPT-NMR delivers complete backbone resonance assignments and secondary structure in ...