When comparing two groups, one receiving an experimental intervention and the other a placebo or nothing, researchers often wish to assess the disparity in risk of experiencing an event of interest, such as onset of disease. Relative risk, relative risk reduction, and odds ratio are often used to measure the association between potential benefit or harm and the intervention. However, these summ...

Background: The predisposing and prognostic factors for neonatal tetanus (NNT) have not been adequately studied in southernIran. Objective: The present study was undertaken in Fars Province to further clarify the status of neonatal tetanus in this region. Methods: The mortality rate was correlated with demographic and clinical findings in 112 cases of neonatal tetanus.  In addition, the height ...

Objective: To conduct a systematic review of rigorously evaluated treatments for infant colic. Methods. Online bibliographic databases were searched for the term “colic” in articles classified as clinical trials or randomized controlled trials and conducted in infants. Reference lists from review articles, meta-analyses, and the selected articles were also reviewed for potential studies. The ab...

Purpose: Breast Cancer (BC) is considered as one of the most dangerous diseases, especially in women. The survivability patient a challenging task if breast cancer severe stage. It very much essential for early classification ultrasound images (BUIs) into several categories such benign (BN), malignant (MG) and normal (NL), etc. so that preventive measures can be taken accordingly at earliest. A...

Abstract Background and purpose Absolute treatment effects of novel oral antidiabetic drugs for cardiovascular outcomes have thus far not been comprehensively evaluated. We aimed to perform a meta-analysis digitalized individual patient data. Methods results Individual from Cardiovascular Outcome Trials (CVOTs) evaluating dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1...

Abstract Background Episodes of acute agitation can occur in individuals who suffer from schizophrenia or bipolar disorder and these be a significant challenge for patients those provide care to them. Sublingual dexmedetomidine is selective alpha2-adrenergic receptor agonist that was recently approved by the US Food Drug Administration treatment adults with disorder. The sublingual form does no...

Abstract Introduction Solriamfetol (Sunosi®), a dopamine/norepinephrine reuptake inhibitor that has been shown to activate TAAR1, is approved (US and EU) treat excessive daytime sleepiness (EDS) in adults with narcolepsy (75-150mg/day) or obstructive sleep apnea (OSA) (37.5-150mg/day). Effect size, number needed (NNT) harm (NNH) are statistical representations of efficacy tolerability clinician...

and commentary also appear in ACP Journal Club. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr J Mant and Professor R Hobbs, University of Birmingham, Birmingham, UK; [email protected] Source of funding: Medical Research Council (MRC). Warfarin v aspirin for preventing stroke in patients >75 year...