Toxicity studies were performed by exposing F344/N rats and B6C3F1 mice to 2- and 4-chloronitrobenzene (CNB) by whole-body inhalation 6 hr/day, 5 days/week, for 13 weeks. Animals were evaluated for clinical chemistry (rats), hematology (rats), histopathology, and body/organ weights. Exposure concentrations were 0, 1.1, 2.3, 4.5, 9, and 18 ppm for 2-CNB and 0, 1.5, 3, 6, 12, and 24 ppm for 4-CNB...

The Dechorinated Zebrafish Embryo Developmental toxicity assay was originally developed from a training set of 31 compounds and reported to be 87% concordant with in vivo teratogenicity data (Brannen, K. C., Panzica-Kelly, J. M., Danberry, T. L., and Augustine-Rauch, K. A. (2010). Development of a zebrafish embryo teratogenicity assay and quantitative prediction model. Birth Defects Res. 89, 66...

Purpose: To further evaluate the safety of Fuganlin Oral Liquid (FGLOL) for clinical application by conducting toxicological tests in young rats.
 Methods: Based on dose infants aged less than 1 year, 4-day-old Sprague-Dawley (SD) rats were orally administered FGLOL3.88, 11.64 and 38.75 g crude drug/kg 18 days, followed a 3-week withdrawal. This was evaluating effect FGLOL various growth d...

Abstract: Background: Ajos sacha is a shrubby herb and has attracted scientists’ attention due to its antioxidative, antineoplastic, larvicidal, antibacterial properties. Hence, assessed in vitro vivo diabetes protective Materials Methods: The methodology started with the quantitative phytochemical estimation of ethanolic extract Adenocalymma alliaceum (EEAA). Then, was studied for cytotoxicity...

A brief overview is provided of some of the general safety and risk assessment procedures used by the different centers of the U.S. Food and Drug Administration (U.S. FDA) to evaluate low-level exposures. The U.S. FDA protects public health by regulating a wide variety of consumer products including foods, human and animal drugs, biologics, and medical devices under the federal Food, Drug, and ...

Ecological risk assessments need to advance beyond evaluating risks to individuals that are largely based on toxicity studies conducted on a few species under laboratory conditions, to assessing population-level risks to the environment, including considerations of variability and uncertainty. Two individual-based models (IBMs), recently developed to assess current risks to sea otters and seadu...

The Joint FAO/WHO Expert Committee recommends the maximum permissible level of zilpaterol in meat to be fixed at 0.5 µg/kg. This is substantiated by results analysis described several research works. Nevertheless, substantiation provided for this recommended standard requires a detailed discussion. In study, we aimed analyze suggestions on (MPL) as per health risks consumers. Our revealed that ...

Bonzi is a new plant growth regulator containing the active ingredient paclobutrazol of triazole chemical class. for use on ornamental plants, such as Chrysanthemum, Perennial Plants, Bedding Foliage Geraniums, Hibiscus and Azaleas, in nurseries greenhouses.
 
 VKM was requested by Norwegian Food Safety Authority to consider potential induce reproductive effects humans; particular rel...

Several treatment regimens with antituberculosis medicinal products are available for tuberculosis. Thiozonide is a newly developed original antimicrobial agent that exhibits bacteriostatic activity against Mycobacterium tuberculosis strains H37Rv, CN-37, CN-40, and MS-115. The aim of the study was to investigate embryotoxic, foetotoxic, teratogenic effects thiozonide in pregnant rabbits. Mater...