10.2217/14750708.5.5.667 © 2 Nocturia is a bothersome and prevalent condition. It affects men and women equally, with an increasing incidence with age. It has multifactorial etiology and therefore treatment is based on an accurate history and examination with an assessment that should include frequency/volume charts and quality-of-life questionnaires. Treatment is primarily aimed at the etiolog...

Nocturia is a major problem in geriatric patients. Clock genes regulate circadian bladder function and Piezo type mechanosensitive ion channel component 1 (Piezo1) that senses fullness. We utilized WT mutant (ClockΔ19/Δ19: nocturia phenotype) mice to determine if the effects of GsMTx4, Piezo1 inhibitor, dependent on expression bladder. compared voiding behavior after administration vehicle, low...

OBJECTIVE The aim of this analysis was to determine the effects of solifenacin in patients considered overactive bladder (OAB) dry at baseline. METHODS This was a pooled analysis of 4 randomized, placebo-controlled 12-week, phase 3 studies. Patients received placebo or solifenacin 10 mg once daily (2 studies), or placebo or solifenacin 5 mg or 10 mg once daily (2 studies). A subgroup of patie...

BACKGROUND Urination disorders are common in Parkinson's disease (PD) and respond poorly to medication. This study aimed to analyze the risk factors for urination disorders in PD. METHODS Ninety-one patients with PD (aged 34-83 years old) were recruited. Patients were assessed with the Unified PD Rating Scale (UPDRS), Hoehn and Yahr stage, Pittsburgh Sleep Quality Index (PSQI), Hamilton Depre...

Abstract Background Nocturia is widely prevalent condition with detrimental effects on quality of life and general health. In Malaysia, there a lack up-to-date prevalence study nocturia. This aimed to investigate the nocturia awareness pertaining among Malaysian adults. Methods A cross-sectional population-based was conducted adults aged ≥ 18 years old. The data collected by mixed mode self-adm...

OBJECTIVES To assess the effect of nocturia on productivity, vitality and utility in a selected group of professionally active individuals with nocturia, compared with matched controls, and investigate the effect of symptom severity, to test the hypothesis that lack of sleep caused by frequent sleep interruptions could reduce an individuals' daytime energy and activity levels. SUBJECTS AND ME...

Nocturia is a common symptom associated with benign prostatic hyperplasia which can persist even after effective treatment of BPH. Other causes may be responsible. We investigated a group of patients who were treated for BPH and continue to have nocturia. Our study has found a high prevalence (85.4%) of nocturnal polyuria in this group of patients. It has important clinical implication since th...