Native alpha-cyclodextrin (alpha-CD) is found to spontaneously form films at aqueous solution/air interfaces. Shape-response measurements to volume perturbations on drops hanging from a capillary indicate that temperature and sodium dodecyl sulfate (SDS) concentration strongly modify the viscoelastic properties of such films. By using isothermal titration calorimetry (ITC), Brewster angle micro...

Microchips for rapid mixing of two aqueous streams have been produced using CaF2 wafers and SU-8 microstructuring technology and tested at the IR beamline of Bessy II in Berlin, Germany. Advantage of the synchrotron radiation over thermal globar sources for measuring at sample spots close to the diffraction limit of the employed mid-IR radiation have been documented. The capability of the exper...

Novel (S)-camptothecin-dextran polymers were obtained by "click" grafting of azide-modified (S)-camptothecin and alkyne-modified dextrans. Two series based on 10 kDa and 70 kDa dextrans were prepared with a degree of substitution of (S)-camptothecin between 3.1 and 10.2%. The binding properties with β-cyclodextrin and β-cyclodextrin polymers were measured by isothermal titration calorimetry and...

Hydroxy Naphthol Blue as a metallochromic indicator in the chelometric measurement of calcium with EDTA provides a very distinct color change at the end-point in the titration of aqueous solutions, serum, and urine samples. Iron, magnesium, copper, phosphate, and bilirubin in concentrations normally encountered in serum and urine did not interfere with the reaction of the indicator. The results...

Chelation reactions of the antimitotic drug, 6-amino-purine (adenine; abbr. ADN) with the metal ions: Be ( I I ) , AI ( I II ) , Cr ( I I I ) , M n ( I I ) , Fe ( I I I ) , Co (II ) , N i ( I I ) , C u ( I I ) , P b ( I I ) , and U 0 2 ( I I ) have been investigated in aqueous solution at 3 0 ° using B j e r r u m C a l v i n pH titration technique. The formation constants have been determined ...

AIMS To compare the safety and efficacy of a simpler titration algorithm for insulin degludec/liraglutide (IDegLira) with that used in previous DUAL trials in insulin-naïve patients with type 2 diabetes. RESEARCH DESIGN AND METHODS This 32-week, open-label, non-inferiority trial randomized adults with type 2 diabetes uncontrolled on metformin ± pioglitazone to receive IDegLira, titrated eithe...

Aqueous hydride transfer is a fundamental step in emerging alternative energy transformations such as H2 evolution and CO2 reduction. "Hydricity," the hydride donor ability of a species, is a key metric for understanding transition metal hydride reactivity, but comprehensive studies of aqueous hydricity are scarce. An extensive and self-consistent aqueous hydricity scale is constructed for a fa...

This study is focused on the composition and the evolution of tungstate ions solutions as a function of pH and increasing concentrations. The Raman analysis showed that, during the titration of the tungstate solutions, WO4(2-), HWO4- ions and probably W2O7(2-) , HW2O7(2-) and H2W2O7 solvated species could exist in aqueous solutions. For diluted solutions, additions of a strong acid does not cau...

The ability of hesperidin (HP) to form complexes with five metals; cobalt, nickel, zinc, calcium and magnesium was investigated. The complexation was studied using U.V spectroscopic titration, in methanol as well as aqueous buffer solutions (physiological conditions). Potential complexes were studied by IR and NMR spectroscopy, melting point and their solubility were also evaluated. The interac...