نتایج جستجو برای: non protein coding rna
تعداد نتایج: 2644200 فیلتر نتایج به سال:
The transcription factor ΔNp63, a master regulator of epithelial biology, is involved in regulating stem cell function and maintaining the integrity stratified tissues such as epidermis. To this end, ΔNp63 acts transcriptional repressor or activator towards distinct subset protein-coding genes microRNAs. However, how whether regulates long non-coding RNA (lncRNAs) expression not known. Here, we...
Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle...
Background: Breast cancer is one of the major causes of illness and mortality among women. Long non-coding RNAs (LncRNAs) have important role in tumor development and progression. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a lncRNA that deregulates in several cancers, however, its value in the diagnosis of breast cancer is unclear. This study was conducted to investigate...
Computationally identifying non-coding RNA regions on the genome has much attention to be investigated. However, it is essentially harder than gene-finding problems for protein-coding regions because non-coding RNA sequences do not have a strong statistical signals. Since comparative sequence analysis is effective for non-coding RNA detection, efficient computational methods are expected for st...
Accumulating evidence suggests that RNAs interacting with genomic regions play important roles in the regulation of genome functions, including X chromosome inactivation and gene expression. However, to our knowledge, no non-biased methods of identifying RNAs that interact with a specific genomic region have been reported. Here, we used enChIP-RNA-Seq, a combination of engineered DNA-binding mo...
Recent studies have revealed that long non-coding RNAs participate in all steps of cancer initiation and progression by regulating protein-coding genes at the epigenetic, transcriptional, and post-transcriptional levels. Long non-coding RNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and these RNAs in naso...
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