The activation of caspase-3 is an important hallmark in Parkinson's disease. It could induce neuron death by apoptosis and microglia activation by inflammation. As a result, inhibition the activation of caspase-3 would exert synergistic dual effect in brain in order to prevent the progress of Parkinson's disease. Silencing caspase-3 genes by RNA interference could inhibit the activation of casp...

The use of next-generation tyrosine kinase inhibitors has led to improved progression-free survival for patients with metastatic non–small cell lung cancer (NSCLC) and those EGFR -mutant ALK -positive tumors. Newer therapeutics can now target KRAS G12C mutations, exon 20 insertions, ERBB2 ( HER2) mutations. Patients NSCLC should undergo molecular testing these mutations as well BRAF mutations; ...

Superoxide ( [Formula: see text] ) has been implicated in the pathogenesis of many human diseases including hypertension. Mitochondria-targeted superoxide scavenger mitoTEMPO reduces blood pressure; however, the structure-functional relationships in antihypertensive effect of mitochondria-targeted nitroxides remain unclear. The nitroxides are known to undergo bioreduction into hydroxylamine der...

Stroke is usually treated by systemic thrombolytic therapy if the patient presents within an appropriate time window. There is also widespread interest in the development of thrombolytic agents that can be used in cases of delayed presentation. Current agents that can be used in cases of delayed presentation of nerve damage by thrombus. Current systemic thrombolytic therapy is associated with a...

(Cell Reports 32, 108033-1–108033-9.e1–e5; August 18, 2020) In the originally published version of this article, Figure 5C accidentally showed same data for EYFP group in DMS and Cortex graphs. The figure legend also erroneously reported number subjects as 6, instead 7. have been corrected, corrected now appears online. authors regret error.Figure 5(corrected). Neuronal Activation by Targeted L...