PURPOSE Neglect of older adults accounts for 60% to 70% of all elder-mistreatment reports made to adult protective services. The purpose of this article is to report data from research, using a risk-and-vulnerability model, that captures the independent contributions of both the elder and the caregiver as they relate to the outcome of neglect. METHODS Between February 2001 and September 2003,...

Groundwater vulnerability assessment is of crucial importance for land use/cover management. Some methods have been proposed specifically for the karst hydrogeological settings. Among them, COP and PaPRIKa, as two commonly applied recent methods, were adopted for the resource vulnerability assessment of a humid temperate karst region, north of Iran. Comparison of water bacterial content and dis...

Tyrosine-containing pharmaceuticals’ (TPh) potential to inhibit SARS CoV-2 3-chymotrypsin-like proteases (3CLpro) and nonstructural protein 16 (NSP16) has been explored using docking studies, molecular dynamics simulations, density functional theory. The TPh with FDA approval showed excellent contact the active site pockets of 3CLpro NSP16. Their binding affinity scores ranged from −5.8 −4.9 kc...

BACKGROUND Patients in recovery following episodes of major depressive disorder (MDD) remain highly vulnerable to future recurrence. Although psychological determinants of this risk are well established, little is known about associated biological mechanisms. Recent work has implicated the default mode network (DMN) in this vulnerability but specific hypotheses remain untested within the high r...

The Sindbis-group alphavirus S.A.AR86 encodes a threonine at nonstructural protein 1 (nsP1) 538 that is associated with neurovirulence in adult mice. Mutation of the nsP1 538 Thr to the consensus Ile found in nonneurovirulent Sindbis-group alphaviruses attenuates S.A.AR86 for adult mouse neurovirulence, while introduction of Thr at position 538 in a nonneurovirulent Sindbis virus background con...

Sindbis virus and Ross River virus are alphaviruses whose nonstructural proteins share 64% identity and whose structural proteins share 48% identity. Starting from full-length cDNA clones of both viruses, we have generated two reciprocal Sindbis-Ross River chimeric viruses in which the structural and nonstructural regions have been exchanged. These chimeric viruses replicate readily in several ...

Although complexity and vulnerability assessment of mountain landscapes is increasingly taken into consideration, less attention is paid to ecophronesis-based solutions so as to reduce the fragile ecosystem vulnerability. The main propose of this study is to provide an insight of mountain complex landscape vulnerability and propose ecophronesis-based solutions in strategic planning framework fo...