Genetic divergence in the form of the mandible is examined in ten inbred strains of mice. Several univariate and multivariate genetic distance estimates are given for the morphological data and these estimates are compared to measures of genealogical and molecular divergence. Highly significant divergence occurs among the ten strains in all 11 mandible traits considered individually and simulta...

BACKGROUND Although ageing workers face specific health and safety concerns, conflicting evidence exists regarding the effects of age on workplace injury rates and workers' compensation claims. AIMS To examine injury and workers' compensation claim rates by age and injury type in an aluminium smelter over a 9-year period. METHODS Routinely collected data for workplace injuries and workers' ...

Nonenzymatic collagen glycation and modification with lipid derived metabolites was studied in rat skin and tail tendon collagen of control and hypertriglyceridemic (HTG) rats. Age-dependent changes typical for lipid and sugar derived adducts were evaluated by measuring fluorescence of these collagens at wavelengths typical for sugar (335/385 and 370/440 nm) and lipid derived adducts (356/460 a...

predictivity by Andrew Knight, Jarrod Bailey and Jonathan Balcombe, which received the Animal Welfare Poster Award from Deutscher Tierschutzbund (the German Animal Welfare Federation) at the 5th World Congress on Alternatives and Animal Use in the Life Sciences, Berlin, 25 August 2005. Reproduced with permission from the complete paper: Knight, A., Bailey, J., Balcombe, J. (2006). Animal carcin...

The northernmost Harbin strain (N strain) of the Asian corn borer, Ostrinia furnacalis enters facultative diapause as fully grown larvae in response to short daylengths; whereas the southernmost Ledong strain (S strain) exhibits almost no diapause under the same light conditions. In the present study, we examined the inheritance of diapause induction and termination by crossing the two strains ...

Tetracycline or doxycycline (dox)-regulated control of genetic elements allows inducible, reversible and tissue specific regulation of gene expression in mice. This approach provides a means to investigate protein function in specific cell lineages and at defined periods of development and disease. Efficient and stable regulation of cDNAs or non-coding elements (e.g. shRNAs) downstream of the t...

Impulsivity, a tendency toward immediate action without consideration of future consequences, is associated with a wide array of problematic behaviors. Response impulsivity, a type of behaviorally-assessed impulsivity characterized by behavioral disinhibition, is also associated with health risk behaviors. Response impulsivity is distinct from choice impulsivity, which is characterized by intol...

If you study a human disease, it is likely that you have tried to generate a mouse model. Sometimes, these models are excellent; others are disappointing. Or, so we think. How often does our mouse mutant not model the human disease because of limitations in how we may look at it? In any living organism, many factors work together to produce the phenotype. Here, new phenotyping paradigms for ass...

Both wild-type (WT) and nonconducting W472F mutant (NCM) Kv1.5 channels are able to conduct Na(+) in their inactivated states when K(+) is absent. Replacement of K(+) with Na(+) or NMG(+) allows rapid and complete inactivation in both WT and W472F mutant channels upon depolarization, and on return to negative potentials, transition of inactivated channels to closed-inactivated states is the fir...

It has been suggested that the collaborative cross, a large set of recombinant inbred strains derived from eight inbred mouse strains, would be a powerful resource for the dissection of complex phenotypes. Here we use simulation to investigate the power of the collaborative cross to detect and map small genetic effects. We show that for a fixed population of 1000 individuals, 500 RI lines bred ...