Catecholamine-induced lipolysis in isolated human adipocytes during the first year of life was investigated. During this period fat cell size increased markedly. Basal and catecholamine-induced glycerol release were positively correlated with age when lipolysis was expressed per cell. However, when lipolysis was expressed per unit of cell surface area (micrometer squared), this correlation was ...

The effects of restraint methods on stress hormones (corticosterone, adrenaline, and noradrenaline), blood biochemistry (glucose lactate), bleeding efficiency were examined in broiler chickens. Thirty 30 male Ross birds randomly allocated to either shackling or cone prior the neck cut. As measures well-being, physiological data such as alterations metabolites hormone levels assessed. Each bird'...

佐藤 哲男 ・岩本 多喜男 ・徳光 幸子 * Though this is not a tranquillizing drug , it is used here as an antiserotonin agent. In the previous report (1), the authors showed that the brain noradrenaline level in rat was induced to elevation, in the state of electric shock, compared with that in non-treated animals. On the other hand, pretreatment with some tranquil lizing;,agents, chlorpromazine, azacyclonol inh...

Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects, however, remain unclear. The inhibitory effects of these antidepressants for neuropathic pain manifest more quickly than their antidepressive ef...

1. Adipocytes isolated from rats 6-9 days after adrenalectomy had significantly increased sensitivity to insulin action against noradrenaline-stimulated lipolysis. In the presence of adenosine deaminase there was no significant difference in insulin sensitivity between cells from adrenalectomized and sham-operated rats. 2. Adipocytes from adrenalectomized rats had decreased lipolytic responses ...

1. Normetanephrine was measured in small samples of plasma and urine of hypertensive patients and normal volunteers (age 20-60 years) by a specific radioenzymatic assay with bovine adrenal phenylethanolamine N-methyltransferase and tritiated S-adenosylmethionine. 2. Noradrenaline was measured simultaneously in plasma and urine. 3. Plasma normetanephrine and noradrenaline concentrations varied i...

Received: 25 October 2007 Accepted: 26 November 2007 j Abstract Neurogenic orthostatic hypotension is a cardinal feature of generalised autonomic failure and commonly is the presenting sign in patients with primary autonomic failure. Orthostatic hypotension can result in considerable morbidity and even mortality and is a major management problem in disorders such as pure autonomic failure, mult...

INTRODUCTION Skin has a large dynamic capacity for alterations in blood flow, and is therefore often used for recruitment of blood during states of hypoperfusion such as during burn shock resuscitation. However, little is known about the blood flow and metabolic consequences seen in the dermis secondary to the use vasoactive drugs (i.e. noradrenaline) for circulatory support. The aims of this s...

1. Noradrenaline stimulates gluconeogenesis through an (a-adrenoceptor in renal cortical tubule fragments from fed rats incubated with 5 mM-lactate. 2. The selective a1-adrenoreceptor agonist methoxamine stimulated gluconeogenesis, but the selective a2-adrenoceptor agonist clonidine was ineffective. 3. The selective a1-adrenoceptor antagonist thymoxamine blocked the stimulatory effects on gluco...

The locus coeruleus is connected to the dorsal hippocampus via strong fiber projections. It becomes activated after arousal and novelty, whereupon noradrenaline is released in the hippocampus. Noradrenaline from the locus coeruleus is involved in modulating the encoding, consolidation, retrieval, and reversal of hippocampus-based memory. Memory storage can be modified by the activation of the l...