OBJECTIVE The aim of this study was to assess which of the basal ovarian reserve markers provides the best reflection of the changes occurring in ovarian function over time (i.e., reproductive aging). DESIGN Prospective longitudinal study. SETTING Healthy volunteers in an academic research center. PATIENT(S) Eighty-one women with normal reproductive performance during the course of their ...

BACKGROUND Assessment of ovarian reserve is one of the steps in the management of infertile couples. Follicle Stimulating hormone (FSH) and anti-Müllerian hormone (AMH) are commonly used ovarian reserve markers in Africa. However, there is paucity of age-specific reference values for FSH and AMH among the African population. OBJECTIVE This study aimed at conducting a pilot study for generatio...

AIM To examine the long term effect of bone marrow transplantation (BMT) on ovarian function in girls. METHODS Eighteen girls who underwent BMT before menarche, had been disease free for more than six years, and were over 14 years of age at the time of study were investigated. The preparative regimen consisted of irradiation and chemotherapy. The occurrence of menarche and changes in basal se...

We have assessed testicular function with luteinising hormone-releasing hormone (LH-RH) and human chorionic gonadotrophin stimulation tests in 44 boys previously treated with, or currently receiving, chemotherapy for acute lymphoblastic leukaemia (ALL). At the same time a testicular biopsy was performed in each boy and the morphology was studied. Histologically the chemotherapy appeared to dama...

different ecologic factors influence on forming, development and sustaining of the plant communities, among which physiographic variables are the most important ones. the aim of this study was to identify forest types and effect of physiographical factors such as sea level height, slope and aspect of the site on quantitative characteristics of forest types in 2nd district of vaz forest with are...

Because the ovarian response to FSH stimulation in assisted reproduction is variable, ranging from hyporesponse to hyperresponse, with the possible complication of ovarian hyperstimulation, it would be of great benefit to predict the response of the patients to FSH. To date, no clear-cut predictors of ovarian responsiveness to FSH have been identified. In this study, we investigated the role of...

The male reproductive hormonal axis Maintenance of normal reproductive function is depend­ ent on the coordinated release of hormones in the hyp o­ thalamic−pituitary−testis cascade. Gonadotropin­releasing hormone (GnRH) is released in a pulsatile pattern into the pitu­ itary portal blood system from neuroendocrine cells in the basal hypothalamus and acts to stimulate gonadotropes in the anter­...

BACKGROUND Delayed puberty can result either from constitutional delay of growth and puberty (CDP) or idiopathic hypogonadotropic hypogonadism (IHH). Gonadotropin-releasing hormone (GnRH) stimulation test has been generally accepted as a current method for diagnosing delayed puberty. The objective of this research was to assess the cut-off values and the efficacy of GnRH stimulation test in the...

OBJECTIVE Raloxifene is a non-steroidal selective estrogen receptor modulator (SERM) that mimics estrogenic activity on bone density and blood lipid concentration without uterotropic actions. Previous data from our laboratory indicated that, as is the case for estrogen, neonatal administration of raloxifene disturbed normal differentiation of the hypothalamic circuitries governing the gonadotro...

To determine the influence of FSH receptor variants Thr307-Asn680 (TN) and Ala307-Ser680 (AS) on ovarian function, we investigated the frequency of these gene polymorphisms by using restriction fragment length polymorphism analysis and observed their effects on clinical manifestations. In a population of 522 Japanese women, the overall frequency of TN/TN (NN), TN/AS (NS), and AS/AS (SS) was 41....