The binding protein (BiP) has been demonstrated to participate in innate immunity and attenuate endoplasmic reticulum- and osmotic stress-induced cell death. Here, we employed transgenic plants with manipulated levels of BiP to assess whether BiP also controlled developmental and hypersensitive programmed cell death (PCD). Under normal conditions, the BiP-induced transcriptome revealed a robust...

Vascular endothelial growth factors (VEGFs) interact with the receptor tyrosine kinases (RTKs) VEGFR-1, -2, and -3; neuropilins (NRPs); and heparan sulfate (HS) proteoglycans. VEGF RTKs signal to downstream targets upon ligand-induced tyrosine phosphorylation, while NRPs and HS act as coreceptors that lack enzymatic activity yet modulate signal output by VEGF RTKs. VEGFs exist in various isofor...

Vascular endothelial growth factor (VEGF), which is known to have at least five isoforms and four receptors, is integral to tumor-induced neovascularization. In order to determine whether VEGF signaling is modulated in the development of cartilaginous tumors, we analyzed osteochondrogenic tumors for the expression of VEGF isoforms and VEGF receptors using the reverse transcription-polymerase ch...

In this paper, a hybridization of Harmony Search Algorithm (HSA) with a greedy shuffle move is proposed for Nurse Rostering Problem (NRP). NRP is a combinatorial optimization problem that is tackled by assigning a set of nurses with different skills and contracts to different types of shifts, over a pre-determined scheduling period. HSA is a population-based method which mimics the improvisatio...

Angus × Gelbvieh cows with 2 to 3 previous pregnancies were used to evaluate effects of maternal nutrient restriction on offspring adipose tissue morphology at standard production endpoints. At 45 d after AI to a single sire, pregnancy was confirmed and cows randomly allotted into groups and fed a control (Con, 100% of NRC recommendations), nutrient-restricted (NR, 70% of Con diet), or nutrient...

In her review of the National Reading Panel's (NRP) report on phonics,Elaine Garan concluded that the report involved "a limited number of studies of a narrow population. . ."1 In this note, I will argue that this problem is not limited to the section on phonics: It also applies to the NRP's section on "fluency." It is only by omitting a large number of relevant studies, and misinterpreting the...

Advanced glycation end-products (AGEs) induce the production of reactive oxygen species (ROS) and extra cellular matrix (ECM) degradation via suppression neuropilin-1 (NRP-1) interaction with AGE-receptors (RAGE). This study aimed to reveal whether modulation NRP-1 by rosuvastatin (RT) prevents AGE-induced renal injury targeting RAGE/matrix metalloproteinase-2 (MMP-2) signaling in diabetic rats...

We argue that Nash’s solution to the bargaining problem should be modified such that it will be based on a New Reference Point (NRP). Such a point is needed so that a player is not considered ‘individually rational’ if he accepts an agreement that provides him with a utility lower than the minimal utility he can derive from any Pareto optimal agreement, or if he accepts an agreement that provid...

Planetary rovers to date have been operated mainly in a serial mode; they are driven from one place to the next, away from the lander, and seldom return to previously visited places. We have been developing a visual navigation technique, called network of reusable paths (NRP), that can be thought of as a low-computational-cost version of simultaneous localization and mapping coupled to a path-t...