Myeloma plasmacytes were studied in six untreated pa tients to obtain more information on the nuclear ultrastruc tural abnormalities in these cells. Asynchrony of nucleolar, nuclear, and cytoplasmic maturation was frequently ob served in pleomorphic myeloma plasmacytes. Immature and mature myeloma plasmacytes of two patients contained intranuclear rodlets which consisted of fine filaments ar ra...

following our previous presentation of a new three-fold symmetry for derivation of the magic numbers of nuclei based upon a quark state model of nuclei, here the nuclear binding energy is obtained from such new perspective. from this point of view, since each nucleon is made of three quarks, the binding energy of nuclei contains a volume term proportional to 3a (a is mass number). by considerin...

Lake Paranoá is a tropical reservoir for the City of Brasilia, which became eutrophic due to inadequate sewage treatment associated with intensive population growth. At present, two wastewater treatment plants are capable of processing up to 95% of the domestic sewage, thereby successfully reducing eutrophization. We evaluated both genotoxic and cytotoxic parameters in several fish species (Geo...

Hutchinson-Gilford progeria syndrome (HGPS) is typically caused by mutations in codon 608 (G608G) of the LMNA gene, which activates a cryptic splice site resulting in the in-frame loss of 150 nucleotides from the lamin A message. The deleted region includes a protein cleavage site that normally removes 15 amino acids, including a CAAX box farnesylation site, from the lamin A protein. We investi...

The nuclear lamina is a thin (20 nm) yet insoluble protein meshwork that, in higher cells, lines the nucleoplasmic face of the nuclear envelope (NE). 1 The lamina is intimately associated with both the inner nuclear membrane and underlying chromatin, while at the same time providing anchoring sites for nuclear pore complexes (Gerace and Burke, 1988). Because of these extensive interactions, the...

Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52-63 years old, were performed in 2001-2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village, Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome abe...

Much of the structural stability of the nucleus comes from meshworks of intermediate filament proteins known as lamins forming the inner layer of the nuclear envelope called the nuclear lamina. These lamin meshworks additionally play a role in gene expression. Abnormalities in nuclear shape are associated with a variety of pathologies, including some forms of cancer and Hutchinson-Gilford Proge...

Reprogramming somatic nuclear function by transplantation of nuclei into recipient oocytes is associated with a morphological remodeling of the somatic nucleus. Successful cloning of animals by nuclear transplantation (NT) demonstrates that reprogramming somatic cell function is possible. However, low pregnancy rates and high frequencies of lethal abnormalities in animals born suggest that repr...

Abstract Cellular liquid–liquid phase separation is a physiologically inevitable phenomenon in molecularly crowded environments inside cells and serves to compartmentalize biomolecules facilitate several functions, forming cytoplasmic nuclear RNA granules. Abnormalities the process granules are implicated onset of neurodegenerative diseases; initial liquid-like phase-separated droplets containi...