Vinculin, a mechanotransducer associated with adherens junctions (AJ) and focal adhesions (FA), plays central role in force transmission through cell-cell cell-substratum contacts. Previously, we generated mice conditional knockout (KO) of vinculin the skin, which results loss bulge stem cell (BuSC) quiescence, promotes continual cycling hair follicles. Surprisingly, found that AJs KO cells are...

Abstract Biophysical cues of the cellular microenvironment tremendously influence cell behavior by mechanotransduction. However, it is still unclear that how cells sense and transduce mechanical signals from 3D geometry to regulate function. Here, mechanotransduction human mesenchymal stem (MSCs) triggered micropattern its effect on paracrine MSCs are systematically investigated. Our findings s...