The histone deacetylase (HDAC) inhibitor vorinostat has received significant attention in recent years as an 'epigenetic' drug used to treat solid tumors. However, its mechanisms of action are not entirely understood, particularly with regard to its interaction with the aberrations in 3D nuclear structure that accompany neoplastic progression. We investigated the impact of vorinostat on human e...

The purpose of this study was to assess cellular proliferative activity of clinically healthy oral mucosal epithelial cells of toombak dippers and smokers by means of AgNOR counts and nuclear areas via nuclear morphometry. Smears were collected from normal-appearing mouth floor mucosa and tongue of 75 toombak dippers, 75 smokers and 50 non-tobacco users between the ages of 20 and 70 with a mean...

Sediments are potentially the internal source that supply nutrients to water in lentic semi-lentic ecosystems. The understanding of factors cause temporal changes sediment properties is critical for management. This study investigated spatial variations and relation their controlling bodies Ishikari River, Northern Japan. Sediment data 29 were measured twice (around 2005 2019) properties, compa...

Abstract Dendropsophus molitor is a hylid frog endemic to the Eastern Cordillera of Colombian Andes, where it exhibits extensive geographic variation in size and colour pattern. Previous multivariate analyses acoustic genetic data suggested that northern southern populations D. were distinct lineages, consequently, described as luddeckei. In this study, we conducted morphometric luddeckei test ...

BACKGROUND Differential diagnosis of thyroid lesions with predominantly follicular pattern is one of the most common problems in thyroid pathology. Development of more objective and reproducible tools for diagnosis is needed. This work is aimed at studying the role of nuclear morphometry in differential diagnosis of different thyroid lesions having predominant follicular pattern. MATERIAL AND...

because of continuous changing of anatomy, function and metabolism of the human brain, age- related change is a major risk factor in most prevalent neurodegenerative diseases, including parkinsons and huntingtons disease. therefore, knowing patterns of age-related atrophy of brain tissue can identify causes and possible role of diseases in decreasing brain function with age. the aim of this stu...

for this study the jejuni of 50 adult (2-4 years), apparently healthy iranian river buffaloes were collectedfrom the abattoir for gross morphology, histomorphology, and histomorphometry. our statistical analysisrevealed that, there are significant (p

background: the preparation of endometrium for embryo reception is dependent on the ovarian hormones, which are affected by ovarian hyperstimulation procedure. objective: the aim of this study was to evaluate the changes in morphometrical indices of endometrium by the daily injection of progesterone after mouse ovarian induction. materials and methods: adult virgin female mice were selected and...