The nuclear morphology of eukaryotic cells is determined by the interplay between lamina forming skeleton, chromatin inside nucleus, and coupling with cytoskeleton. Nuclear alterations are often associated pathological conditions as in Hutchinson-Gilford progeria syndrome (HGPS), which a mutation lamin A gene yields an altered form protein, named progerin, aberrant shape. While genetic molecula...

We analysed the architecture of cardiomyocyte nuclei lacking lamin A activity in three patients with dilated cardiomyopathy. The diagnosis was established on the basis of clinical and electrophysiological examinations, chest radiography and electrocardiography. An ultrastructural study of affected cardiomyocytes showed dramatic alterations in nuclear distribution and organization affecting nucl...

The premature aging disorder, Hutchinson-Gilford progeria syndrome (HGPS), is caused by mutant lamin A, which affects the nuclear scaffolding. The phenotypic hallmark of HGPS is nuclear blebbing. Interestingly, similar nuclear blebbing has also been observed in aged cells from healthy individuals. Recent work has shown that treatment with rapamycin, an inhibitor of the mTOR pathway, reduced nuc...

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We compare the fractions of the hard and geometric cross sections as a function of impact parameter. For a given definition of central collisions, we calculate the corresponding impact parameter and the fraction of the hard cross section contained within this cut. We use charm quark production as a definite example. In this note, revised from Ref. [1], standard nuclear density distributions are...

Oxidative liver injury during steatohepatitis results in aggregation and transglutaminase-2 (TG2)-mediated crosslinking of the keratin cytoplasmic intermediate filament proteins (IFs) to form Mallory-Denk body (MDB) inclusions. The effect of liver injury on lamin nuclear IFs is unknown, though lamin mutations in several human diseases result in lamin disorganization and nuclear shape changes. W...