It has been shown previously that the muscarinic cholinergic system in the nucleus raphe magnus (NRM) is involved in the modulation of nociception. In this study, we examined the direct actions of muscarine on the NRM neurons in a slice preparation. Muscarine (1-30 microM) produced a dose-dependent hyperpolarization in a subpopulation of the NRM cells that contain 5-hydroxytryptamine (5-HT). In...

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Serotonergic cells are located in a restricted number of brain stem nuclei, send projections to virtually all parts of the CNS, and are critical to normal brain function. They discharge tonically at a rate modulated by the sleep-wake cycle and, in the case of medullary serotonergic cells in raphe magnus and the adjacent reticular formation (RM), are excited by cold challenge. Yet, beyond behavi...

Anonymous artefacts and revealing runes – Scandinavian runic artefacts from a gender perspective The aim of this paper is to examine a group of runic artefacts dated to the Viking Age (800-1050 AD) from a gender perspective. The analysed material consists of 59 runic artefacts from Scandinavia, which differ in regards to base material, context and content. In the analysis, the material is separ...

Recent advances in theory of solid state nuclear magnetic resonance (NMR) such as Floquet-Magnus expansion and Fer expansion, address alternative methods for solving a time-dependent linear differential equation which is a central problem in quantum physics in general and solid-state NMR in particular. The power and the salient features of these theoretical approaches that are helpful to descri...

This monograph reports a series of outstanding and entirely unexpected results by the authors, in part purely mathematical, and in part belonging to the branch of mathematical science that studies financial markets. It involves a new conception of probability, which the authors call “game-theoretic probability”, but I would prefer to call “market probability”. (Whenever a new scientific approac...

All neuronal networks are modulated by multiple neuropeptides and biogenic amines. Yet, few studies investigate how different modulators interact to regulate network activity. Here we explored the state-dependent functional interactions between three excitatory neuromodulators acting on neurokinin1 (NK1), alpha1 noradrenergic (alpha1 NE), and 5-HT2 serotonin receptors within the pre-Bötzinger c...

The role of raphe nucleus (R.N) and serotonin in some behaviors such as sleep, cognition, mood, and memory has previously been reported. The median raphe (MR) nucleus is a major serotonin-containing cell group within the brainstem and is one of the main sources of projections to the septum and hippocampus. The hippocampus is widely believed to be essential for context-conditioning learning. Mor...