The cooperative antitumor effects of IL-12 and IL-15 gene transfer were studied in the N592 MHC class I-negative small cell lung cancer cell line xenotransplanted in nude mice. N592 cells engineered to secrete IL-15 displayed a significantly reduced tumor growth kinetics, and a slightly reduced tumor take rate, while N592 engineered with IL-12 displayed only minor changes in their growth in nud...

OBJECTIVE To investigate the ability of B152 to block cancer growth in cell lines in vivo and in nude mice in vitro. STUDY DESIGN We examined JAR, JEG-3, and NTERA trophoblastic cancer cell lines and KLE, Hec-1A, SCaBER, and T24 nontrophoblastic cancer cell lines. JEG-3 cells were transplanted into 8 nude mice. Four nude mice were administered B152 antibody, and 4 were administered control no...

This study investigated the inhibitory effect and mechanism of curcumol on growth human hepatocellular carcinoma (HCC) HepG2 xenografts in nude mice. Curcumol was isolated from zedoary turmeric oil. The xenograft model mice established. Forty modeled were divided into model, cisplatin, cisplatin+curcumol groups. latter three groups treated with 2 mg/kg 100 cisplatin combined curcumol, respectiv...

Abstract Background To date, glioblastoma (GBM) remains a fatal disease, with median overall survival of roughly over year. There is crucial need new treatment options, yet most clinical trials have failed partly due to the lack predictive preclinical model systems. Currently, patient-derived models suffer from reduction or absence immune system components, which represents bottleneck for adequ...

STGC3 is a potential tumor suppressor in nasopharyngeal carcinoma. We previously found that CNE2 cells that re-expressed STGC3 formed smaller tumors in female mice than in male mice. Here, we investigated the sexual dimorphism of STGC3 as a tumor-suppressor in female and male nude mice injected subcutaneously with pcDNA3.1(+)-STGC3/CNE2 cells. ER-α was positively expressed in vitro in the CNE2 ...

A 58-year-old man with bronchogenic oat cell carcinoma developed a typical syndrome of inappropriate secretion of antidiuretic hormone. The tumor tissue obtained at autopsy had been serially transplanted in nude mice for more than four years with 20 passages. The levels of vasopressin were remarkably increased in the plasma of nude mice bearing this tumor [24.4 +/- 18.3 (S.D.) pg/ml, n = 3] as ...

A human immature teratoma cell line was established from tumor tissue of the ovary. The cell line, designated YK , synthesized and secreted alpha-fetoprotein, but there was a gradual decrease in the synthesis of this protein during serial passage. The doubling time at passage 43 was about 20.3 hr, and the plating efficiency was 30 to 40%. Tumorigenicity of the cell line in athymic nude mice was...

BACKGROUND AND OBJECTIVE Methylseleninic acid (MSA) is an artificially developed selenium compound. It has been proven that MSA could inhibit growth and metastasis on many tumor cells. This study investigated whether MSA has an impact on the growth and metastasis of L9981-Luc lung cancer transplanted model in nude mice or not. METHODS A transplantated tumor model was established in nude mice....

The purpose of this study was to determine whether the methods for isolating tumor cells from a human renal cell carcinoma (HRCC) influ ence the biological behavior of the cancer cells. Renal cell carcinoma obtained from a surgical specimen was dissociated by enzymatic treatment and cells were plated into culture dishes or injected s.c. into the kidney of BALB/c nude mice. The resultant kidney ...