Abstract Background Pellagra is a nutritional disorder due to deficiency of vitamin B3 (niacin) which characterized by dermatitis, dementia, diarrhea, and death. The most common site dermatitis in pellagra the Casal necklace; however, this case, presentation unusual sites. Therefore, mucocutaneous signs play major role diagnosing condition. clinical features begin with gastrointestinal symptoms...

We report on a child in whom severe nutritional vitamin B12 deficiency was exacerbated by a genetic impairment of the folate cycle, causing reduced CSF concentrations of the methyl group donor 5-methyltetrahydrofolate. Some patients with vitamin B12 deficiency may benefit from high dose folic acid supplementation, even if plasma concentrations are high.

Introduction: Glutaric academia type I is a metabolic disorder that is caused due to deficiency of glutaryl-CoA dehydrogenase. Macrocephaly is a common sign in GA1, although many infants usually appear healthy at birth.   Case Report A 5.5 year old boy with GA1was admitted to NICU. Chief compliance of patient for hospitalization was pneumonia and sepsis and he was intubated and mechanically ven...