Neurofibromatosis (NF) is a multisystem disorder and tumor predisposition syndrome caused by genetic mutation on chromosome 17-17q11.2 in NF type 1 (NF1), and on chromosome 22-22q12.2 in NF type 2. The disorder is characterized by considerable heterogeneity of clinical expression. NF1 is the form with the most characteristic ocular manifestations. Lisch nodules of the iris are among the well-kn...

Ocular developmental disorders, including the group classified as microphthalmia, anophthalmia, and coloboma (MAC) and inherited retinal dystrophies, collectively represent leading causes of hereditary blindness. Characterized by extreme genetic and clinical heterogeneity, the separate groups share many common genetic causes, in particular relating to pathways controlling retinal and retinal pi...

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are drug-induced acute inflammatory vesiculobullous reactions of the skin and mucous membranes, including the ocular surface. Even after recovery from skin symptoms, some SJS/TEN patients continue to suffer with severe ocular complications (SOCs). Therefore, this study aims to understand the pathophysiology...

the histopathologic diagnosis of orbital and ocular adnexal lymphoproliferative lesions is difficult, resulting controversy in classification, determining benignity or malignancy of them and treatment modality selection. we designed the following study to evaluate clinical, histopathologic and if necessary immunochemical features of them in decreasing indeterminate cases. the study includes 51 ...

background: atrazine (atr) is used as an agriculture herbicide worldwide. it has been shown that atr adversely affect the reproductive system in rodents. in this study we aimed to evaluate the impact of chronic exposure to atrazine (atr) on male testicular tissue, sperm parameters, serum level of total thiol molecules (ttm) and malodialdehyde (mda) content of testes. methods: to follow-up this ...

background: toxoplasma gondii , an apicomplexan parasite, is capable of infecting a broad range of intermediate warm-blooded hosts including humans. the parasite seems to be capable of altering the natural behavior of the host to favor its trans-mission in the environment. the aim of this study was to evaluate the course, alter-ations in behavior along with normal kinetics of the abnormally ind...

The microcirculation plays a major role in maintaining homeostasis in the body. Alterations or dysfunctions of the microcirculation can lead to several types of serious diseases. It is not surprising, then, that the microcirculation has been an object of intense theoretical and experimental study over the past few decades. Mathematical approaches offer a valuable method for quantifying the rela...

BACKGROUND AND AIM: Ocular disorder like, diplopia, mydriasis, blurred vision, ptosis, exophthalmos, and blindness (permanent or temporary) are infrequent complications of an injection of local anesthetics in mouth.The main purpose of this study was to survey the dentist’s knowledge and attitude about ocular disorders due to intra-oral anesthetics injection.<br...

UNLABELLED The use of ocular prostheses for ophthalmic patients aims to rebuild facial aesthetics and provide an artificial substitute to the visual organ. Natural intemperate conditions promote discoloration of artificial irides and many studies have attempted to produce irides with greater chromatic paint durability using different paint materials. OBJECTIVES The present study evaluated the...