Diseases or disorders affecting the posterior segment of the eye, such as diabetic retinopathy, age related macular degeneration and retinitis pigmentosa, are the leading causes of decreased visual acuity and blindness. Successful treatment modalities require generation and maintenance of therapeutically effective drug concentrations at the target sites: vitreous, retina and/or choroid. Drug de...

in order to achieve prolong corneal contact time of norfloxacin(nfx) for treatment of extra ocular diseases, a ph triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. nfx loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

Several critical ocular diseases that can lead to blindness are due to retinal disorders. Subretinal drug delivery has been developed recently for the treatment of retinal disorders such as hemorrhage because of the specific ocular structure, namely, the blood retinal barrier (BRB). In the present study, we developed an Arched Micro-injector (ARCMI) for subretinal drug delivery with minimal ret...

Drug delivery carriers can maintain effective therapeutic concentrations in the eye. To this end, we developed lipid nanoparticles (L/NPs) in which the surface was modified with positively charged chitosan, which engaged in hydrogen bonding with the phospholipid membrane. We evaluated in vitro corneal permeability and release characteristics, ocular irritation, and drug dynamics of modified and...

Gamma-scintigraphy is applied extensively in the development and evaluation of pharmaceutical delivery systems, particularly for monitoring formulations in the gastrointestinal and respiratory tracts. The radiolabelling is generally achieved by the incorporation of an appropriate radionuclide such as technetium-99m or indium-111 into the formulation or by addition of a non-radioactive iso...

Ocular drug delivery is one of the most fascinating and challenging endeavours facing the research world of pharmaceutics. The poor uptake of many ocular drugs is mainly due to the rapid elimination process by tear turnover. A prolonged precorneal residence time would result in higher absorption for some drugs, a prolonged duration of their therapeutic effect. Recently, in-situ gel formulations...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

There has been considerable interest in the potential application of contact lenses for ocular drug delivery. This short communication provides an overview of the challenges faced by delivering drugs using contact lenses, highlights the solutions to limitations that have already been achieved, and describes the barriers that remain before commercial application can be realized. *Corresponding a...

Poor ocular bioavailability of drugs (<1%) from conventional eye drops (i.e., solution, suspension, and ointments) is mainly due to the physiologic barriers of the eye. In general, ocular efficacy is closely related to ocular drug bioavailability, which may be enhanced by increasing corneal drug penetration and prolonging precorneal drug residence time. In our current work, we developed a collo...

This report describes the efficacy of a novel mucoadhesive polymer, the tamarind seed polysaccharide, as a delivery system for the ocular administration of hydrophilic and hydrophobic antibiotics. Healthy rabbits were subjected to repeated ocular instillations with either conventional gentamicin or ofloxacin or these agents viscosified with the tamarind seed polysaccharide. Administration of vi...