OBJECTIVE To examine ocular outcomes and survival after proton irradiation in patients with peripapillary and parapapillary melanomas ineligible for the Collaborative Ocular Melanoma Study. METHODS A total of 573 patients who received proton irradiation from January 4, 1985, through December 24, 1997, for tumors located within 1 disc diameter of the optic nerve, and therefore ineligible for t...

The canonical Wnt/Fzd signaling pathway is highly conserved among various species. Increasing evidence is accumulating for non-canonical Wnt signaling pathways, analogous to those discovered in Drosophila, being operative in vertebrates. Similarly, the networks of genes involved in eye development show significant conservation during evolution. The amenability of Drosophila for genetic manipula...

BACKGROUND AND PURPOSE Volumetry may be useful for evaluating treatment response and prognosis of intraocular lesions. Phantom, volunteer, and patient studies were performed to determine whether ocular MR volumetry is reproducible. MATERIALS AND METHODS Half-Fourier single-shot RARE and FSPGR sequences at 1.5T with a 76-mm-diameter surface coil were optimized to obtain still ocular images. Vo...

AIM Melanoma represents a malignant tumour arising from melanocytes. Uveal melanoma is the most common primary ocular malignancy among the adult population. The aim of the study was to examine epidemiological characteristics of ocular melanoma in University Clinic Centre in Tuzla, Bosnia and Herzegovina from January 2001 till November 2015. METHODS AND MATERIALS In this retrospective study we...

Experimental evidence of intrinsic localized modes (ILMs) in microelectromechanical oscillator arrays has been reported recently. In this paper, we carry out a detailed analysis of a new mechanism for ILMs in typical experimental settings; that is, spatiotemporal chaos is ubiquitous and it provides a natural platform for actual realization of various ILMs through frequency control. We find that...

OBJECTIVES To report an important complication of ocular evisceration therapy for blind, painful eyes that has been unreported in the literature, and to stress the need for careful preoperative evaluation to exclude occult neoplasms prior to therapy. DESIGN Multicenter, retrospective, nonrandomized clinicopathological case series of patients found to have previously unsuspected uveal malignan...

PURPOSE To report the diagnoses of lesions initially misdiagnosed as ocular melanoma. METHODS This retrospective study included all new patients who were referred with a presumptive diagnosis of choroidal melanoma to the ocular oncology clinic at Farabi Eye Hospital from January 2009 to December 2012. Each patient underwent a full ocular examination and B-scan ultrasonography by an ocular onc...

A 65–yrs-old man referred for an ocular discomfort and red eye. The clinical diagnosis was leech in the left eye and its species confirmed as being Limnatis nilotica. Ocular leech infestation should be considered in patients with a history of swimming or washing their face in streams and lakes. Attention should also be given to ocular leech infestation in the differential diagnosis of ocular tr...

5-Ethylamino-9-diethylaminobenzo[a]phenothiazinium chloride (EtNBS) is a novel photodynamic therapy (PDT) photosensitizer with efficacy against experimental murine tumors. In this preliminary study, dogs and cats with naturally occurring tumors were treated with EtNBS-PDT to determine safety and efficacy. Fifteen treatments were performed on 13 animals (9 treatments in 8 cats and 6 treatments i...

INTRODUCTION Some eyelid defects require reconstruction. OBJECTIVE To study the eyelid conditions requiring reconstruction among the patients attending an oculoplasty clinic of a tertiary level eye institute. MATERIALS AND METHODS All the cases of eyelid reconstruction surgery of two years were retrospectively included in this study. The parameters studied were causes of eyelid defects, age...