19 19 QUESTIONS • CHALLENGES • CONTROVERSIES Dapsone, first developed in 1908, was initially intended for oral treatment of infectious diseases; however, dapsone was later shown to have potent anti-inflammatory properties. The anti-inflammatory mechanisms of dapsone appear to be separate from its antibacterial properties. Oral dapsone has been shown to be efficacious for dermatoses with neutrop...

Sir, We read with great interest the recent letter by Sadjadi & Moshir (1) concerning the treatment of acne vulgaris with colchicine. The authors reported an improvement in all 22 selected patients after 2 months of administration of a daily dose of 1 mg of colchicine. The effectiveness of the drug was more evident in the patients with severe acne vulgaris. They recommended this drug as a possi...

Granuloma Annulare is an flammatory bening skin disease that may manifest different clinical features.the most common presentation or classic form of the disease is fleshcolor,annulare,grouped papules,disseminated forms are rare and responses to treatments are vnot satisfactory.various treatment modalities have been used for this disorder and different responses to treatments have been reported...

Although rare, severe hidradenitis suppurativa (HS) of the anal, perianal, gluteal, thigh, and groin regions can evolve into squamous cell carcinoma (SCC). This usually does not occur until the HS has been present for more than 20 years. Malignant degeneration of HS in the axilla has not been reported. SCC has developed in dissecting cellulitis, acne conglobata, and pilonidal cysts (other membe...

The intensity of human-induced impacts on the distribution and diversity of macroinvertebrates and water quality of Gbako River, North Central, Nigeria, was evaluated monthly for 6 months using modified kick sampling techniques. Four study stations were selected along the river course (upper reaches of less human impacts through mid-reaches with relative high human impacts to lower reaches of l...