Advanced maternal age is associated with the natural oocyte depletion, leading to low yield, high infertility treatment cancellation rates, and eventual decreases in pregnancy rates. Various innovative interventions have been introduced improve outcome of for aging patients. Numerous published data demonstrated that early follicle development was regulated by intraovarian growth factors through...

background: human chorionic gonadotropin (hcg) has been used as a replacement for the mid-cycle luteinizing hormone (lh) surge for several years. the recent arrival of recombinant dna technology has made recombinant hcg (rhcg) accessible. objective: to assess efficacy of rhcg compared to urinary hcg (uhcg) for triggering of ovulation and induction of final oocyte maturation in assisted reproduc...

2. The biology of the oocyte . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 2.1. Oogenesis and development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 2.2. Bioelectrical properties of the oocyte . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 2.3. The oocyte at work...

Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular microenvironment and maternal signals, mediated primarily through granulosa cells (GCs) and cumulus cells (CCs), are responsible for nurturing oocyte growth, development and the gradual acquisition of oocyte devel...

Histological analysis was carried out on ovarian development in the picnic seabream, Acanthopagrus berda (Forsskål 1775) caught estuarine waters of Calicut, Kerala, India from January to December 2016. Four developmental phases oocyte were identified viz., oogonia proliferation and transformation into primary oocyte, growth phase, secondary phase maturation these are similar those described for...

Intracellular Ca(2+) oscillations at fertilization are responsible for triggering egg activation. The aim of this study was to examine the effect of the age of the oocyte donor and in-vitro maturation on the generation of Ca(2+) transients at fertilization. The results show that <10% of in-vivo and in-vitro matured oocytes from 19-day old mice develop to the blastocyst stage in vitro. In contra...

BACKGROUND Mammalian oocyte stocks reach maximum size in early development and begin depletion immediately thereafter. This depletion ends women's fertility by midlife. Here we compare five models proposed to characterize human follicular depletion, highlight underlying variation in atresia, and use oocyte counts from laboratory mice to illustrate possible effects of known covariates. METHODS...