background: cutaneous manifestations are commonly observed in the neonatal period. it is important to differentiate physiologic skin lesions from pathologic ones to avoid parents’ concerns. regarding this, the current study aimed to investigate the frequency and localization of salmon patch (sp) and mongolian spot (ms) in iranian newborns to assess the potential relationship between the neonata...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

BACKGROUND The 5% Lidocaine patch is used for treating chronic neuropathic pain conditions such as chronic back pain (CBP), diabetic neuropathy and complex regional pain syndrome, but is effective in a variable proportion of patients. Our lab has reported that this treatment reduces CBP intensity and associated brain activations when tested in an open labelled preliminary study. Notably, effect...

A aspect of better and more secure software is timely patch release by software vendors for the vulnerabilities in their products. Software vulnerability disclosure, which refers to the publication of vulnerability information, has generated intense debate. An important consideration in this debate is the behavior of software vendors. How quickly do vendors patch vulnerabilities and how does di...

The mechanosensitivity of the epithelial sodium channel (ENaC) is controversial. Using cell-attached patch-clamp techniques, we found that mechanical stretch stimulated ENaC in A6 distal nephron cells in only three of nine cell-attached patches. However, stretch consistently activated ENaC after apical ATP was scavenged with apical hexokinase plus glucose or after P(2) receptors in the patch we...

Optimizing land-use allocation is important to regional sustainable development, as it promotes the social equality of public services, increases the economic benefits of land-use activities, and reduces the ecological risk of land-use planning. Most land-use optimization models allocate land-use using cell-level operations that fragment land-use patches. These models do not cooperate well with...

Most studies of the evolution of sexual ornamentation have dealt with plumage attributes. White plumage patches are widespread in birds, the disproportionate role of wearing costs makes their evolutionary trajectories unique, and their visual assessment is less biased than that of other color categories. Still, comparative studies of white patches are very rare. We examined the evolution of whi...

Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. This study was initiated to help determine the optimal patch test preparation for MDBGN. In 51 patients with a doubtful or a positive patch test reaction to at least 1 of 4 test preparations with MDBGN in petrolatum at 1.0% w/w, 0.5%, 0.3% and 0.1%, a repeated open applica...

Political arguments and voting requirements often follow a simple majority method which is a decision rule that selects various alternatives that have a majority, that is, more than half the votes. On the other hand, Q&A services such as StackExchange and Yahoo! Answers use the simple majority method only as a reference point. In other words, even if an answer receives a majority vote (which re...

the dynamic response of a transversely isotropic, linearly elastic layer bonded to the surface of a half-space of a different transversely isotropic material under arbitrary shape surface loads is considered. with the help of displacements and stresses green’s functions, an analytical formulation is presented for the determination of the displacements and stresses at any point in both surface l...