BACKGROUND AND OBJECTIVES Hemodialysis (HD)-induced regional wall motion abnormalities (RWMAs) are common in HD patients and driven by ischemia. In nondialysis patients, repeated ischemia leads to chronic reduction in left ventricular (LV) function. HD-induced myocardial ischemia may initiate the same process. We examined the effect of HD-induced repetitive myocardial stunning on global and reg...

OBJECTIVES The present study was carried out to determine whether inhalation of hydrogen (H(2)) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. DESIGN In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% o...

BACKGROUND Impaired endothelial-dependent vascular responses after coronary artery occlusion (CAO) and reperfusion (CAR) have been investigated extensively. However, it is not known whether impaired endogenous endothelium-derived relaxing factor production affects postischemic myocardial dysfunction, ie, myocardial stunning. METHODS AND RESULTS Eight dogs were instrumented with an intracorona...

Background Patients with ischemic cardiomyopathy (CMP) often develop regional wall motion abnormalities (WMA) due to myocardial scarring, stunning or hibernation. Abnormal functioning myocardial segments without evidence of fibrosis on late gadolinium-enhancement cardiac magnetic resonance (LGE-CMR) are felt to represent stunned or hibernating myocardium, presumably with significant coronary ar...

Complication rates in 1,000 consecutive patients who underwent radical retropubic prostatectomy for clinically localized prostate cancer between November 1989 and January 1992 were assessed and compared to complication rates in a historical group of patients operated on by primarily the same surgeons prior to 1987. In the contemporary series, there were no operative deaths, only 22% of patients...

See article by Burgdorf et al. [11] (pages 713 –720) in whereas the response to exogenous noradrenaline is unafthis issue. fected [9]. What is the mechanism behind neuronal stunning? It A brief period of ischaemia is known to induce a was initially suggested by Miyazaki and Zipes [8] that high prolonged period of reversible myocardial dysfunction potassium, low pH and adenosine each could inhib...

Brief ischemic episodes confer marked protection against myocardial stunning 1-3 d later (late preconditioning [PC] against stunning). The mechanism of this powerful protective effect is poorly understood. Although protein kinase C (PKC) has been implicated in PC against infarction, it is unknown whether it triggers late PC against stunning. In addition, the entire PKC hypothesis of ischemic PC...

We used an anesthetized swine model of regionally "stunned" myocardium to determine the effect of stunning on coronary autoregulation and blood flow heterogeneity. In 18 domestic swine, stunning was accomplished by reducing blood flow to the left anterior descending coronary artery (LAD) by approximately 75% of baseline for 15 min and restoring it to normal for 1 hour. We quantified coronary au...