BACKGROUND Patients on linezolid-containing drug-resistant TB (DR-TB) regimen often develop adverse-events, particularly peripheral and optic neuropathy. Programmatic data and experiences of linezolid-associated optic neuropathy from high DR-TB burden settings are lacking. The study aimed to determine the frequency of and risk-factors associated with linezolid-associated optic neuropathy and do...

purpose : to evaluate the effects of memantine on improving visual function in patients with acute nonarteritic anterior ischemic optic neuropathy (naion) methods : this was a prospective, double masked, randomized, clinical trial. the study involved 47 subjects with unilateral naion of less than 8 weeks duration. eligible patients were randomly allocated to take either memantine tablets (5 mg ...

purpose : evaluation of efficacy of memantine (n-methyl-d-aspartate receptor antagonist) on visual function of patients with acute non-arteritic ischemic optic neuropathy (naion). methods : the study was conducted as interventional case series from november 2005 through november 2006 in farabi eye hospital . twenty-two patients with acute naion of less than 8 weeks duration entered the study. m...

background: sleep apnea is temporary cessation or absence of breathing during sleep. significant increase in blood pressure is clinically seen in apneic episodes. the aim of this study was to examine sleep apnea syndrome as a risk factor for non- arthritic anterior ischemic optic neuropathy (naion) in a case control study. methods: nineteen naion patients (9 men and 10 women) and 31 age and sex...

InTRoDUCTIon Inflammatory, demyelinating optic neuritis is one of the most common optic neuropathies in young adults. It occurs idiopathically, or in association with multiple sclerosis, and follows a typical course of progressing visual dysfunction often with pain for one – two weeks, followed by significant resolution over the next few weeks. Due to the characteristic presentation and frequen...

Although the transcription factor, nuclear factor survival, its precise role in cell death within the central nervous system (CNS) remains unknown. previously reported that mice with a homozygous deficiency for NF optic neuropathy. We examined the expression and activation of pro mediate optic neuropathy in p50 known to regulate the recombination of immunoglobulin V(D)J. Experiments with gene e...

Injury to the optic nerve can lead to axonal degeneration, followed by a gradual death of retinal ganglion cells (RGCs), which results in irreversible vision loss. Examples of such diseases in human include traumatic optic neuropathy and optic nerve degeneration in glaucoma. It is characterized by typical changes in the optic nerve head, progressive optic nerve degeneration, and loss of retinal...

Inherited optic neuropathies are a heterogeneous group of disorders characterized by mild to severe visual loss, colour vision deficit, central or paracentral visual field defects and optic disc pallor. Optic atrophies can be classified into isolated or non-syndromic and syndromic forms. While multiple modes of inheritance have been reported, autosomal dominant optic atrophy and mitochondrial i...

Key words: haemodialysis; hypotension; ishcaemic optic neuropathy with oedema of the papillo-macular area. Both central retinal arteries were patent. No optic neuropathy; visual loss neurological deficit was detected. Brain computed tomography was normal and magnetic resonance imaging of the brain showed lesions compatible with