This paper presents multi-objective optimization analysis and experimental implementation of a single column isocratic supercritical fluid chromatography process for the enantioseparation of flurbiprofen. The single column process is simulated using a detailed model with equilibrium description by a competitive Langmuir isotherm. The optimization problem has been formulated with the objectives ...

bacillus sp. guf8, isolated from acidic soil samples of a tea farm was identified as bacillus cereus, based on 16s rdna sequencing and standard bacterial identification methods. following optimization of enzyme production, the resulting α-amylase was purified by acetone precipitation and ion exchange chromatography. consequently, thermostability and kinetic parameters of the purified enzyme wer...

This work reviews a well-known methodology for batch distillation modeling, estimation, and optimization but adds a new case study with experimental validation. Use of nonlinear statistics and a sensitivity analysis provides valuable insight for model validation and optimization verification for batch columns. The application is a simple, batch column with a binary methanol-ethanol mixture. Dyn...

Fig. 2 The three z-shim images evaluated by real time optimization are combined into a MIP image showed in the 4 column. The MIP image consisted of three z-shim images by traditional z-shimming method is showed in the 5 column. Fig. 1 The comparison of real time optimization and traditional z-shimming sweep. Each spot means the intensity summation of z-shim image. The black star symbol indicate...

The optimization of discontinuous (or hybrid) dynamic systems is considered. In particular, the potential of numerical optimization procedures to make optimal sequencing decisions in hybrid dynamic systems is explored. A general formulation for hybrid optimal control is presented. Further analysis yields a nonsmooth formulat ion for parameter optimization of hybrid dynamic systems, which may al...

Based on two integration steps, an optimization framework is proposed in this work for the synthesis and design of complex distillation sequence. The first step is to employ heat integration in sequence and reduce the heat consumption and total annual cost of the process. The second one is to increase the exergetic efficiency of sequence by generating power in implemented expanders in sequence....

Modified Bubble Column Extraction with Ultrasonic Bath (BCE-UB) method was used to extract atropine from the stem and leaves of Atropa belladonna. Optimum condition were obtained with Kamada solvent which was chloroform-methanol-ammonia 15:15:1(v/v/v) as extraction solvent, the particle size of  less than  350 µm, an extraction time of 23.95 min, a liquor to material ratio of 15.08 mL/g and...