The purpose of this study was to evaluate the pharmacokinetic behavior of florfenicol spray-dried nanosuspersion after oral administration to rabbits and to compare its oral bioavailability characteristics to that of a known soluble powder. Florfenicol spray-dried nanosuspersion was produced by high pressure homogenization followed by spray drying. Plasma concentrations were determined by HPLC....

Plasma concentrations of ethynyl oestradiol and norethindrone in women were measured by radioimmunoassays after oral administration of 50 microng and 1000 microng respectively. The maximum values were obtained 1 h after administration. The calculated half-life was 6 1/2 h for ethynyl oestradiol and 7 h for norethindrone. At most 2-3% of the administered dose was present in the plasma at 1 h and...

Concentrations of cyclacillin in serum over a 6-h period were similar in fasted and milk-fed infants who received 25-mg/kg doses of cyclacillin suspension. Measured by the concentration in serum after oral administration of 15-mg/kg doses, cyclacillin was absorbed more rapidly, reached larger concentrations, and was cleared more promptly than was amoxicillin.

Absorption and elimination of fluconazole after oral administration of a 100-mg capsule were unaffected by concomitant administration of an antacid containing aluminum and magnesium hydroxides.

To evaluate the bioavailability of a new theophylline preparation suitable for once-a-day (od) oral administration, we performed a nonrandomized crossover study in which the absorption of the OD and a standard twice-a-day (bid) preparation were compared. Eight stable asthmatic patients, after having achieved steady-state, received an average of 975 mg of OD preparation at 8 PM. The protocol was...

(a) An over-the-counter analgesicantipyretic drug product in a form suitable for oral administration is generally recognized as safe and effective and is not misbranded if it meets each of the conditions in this part in addition to each of the general conditions established in § 330.1 of this chapter. (b) References in this part to regulatory sections of the Code of Federal Regulations are to c...

In a preliminary study, ewes received daily oral cadmium chloride administrations and cadmium concentration was measured in blood and tissues. A pharmacokinetic analysis of cadmium disposition was then carried out in ewes administered cadmium chloride iv and, 21 months later, orally in the same ewes. Pharmacokinetic parameters were analysed using a 3-compartment open model. The systemic availab...

1. Retinyl methyl ether was converted into vitamin A in vitamin A-deficient rats regardless of whether administered by oral, intraperitoneal, intramuscular or subcutaneous route; intramuscular administration seemed to be the best for conversion as well as storage. 2. Significantly, unchanged retinyl methyl ether was also found in the liver after oral administration but not after administration ...

MDMA (3,4-methylenedioxymethamphetamine or "ecstasy") is a recreationally used drug with remarkable and characteristic prosocial effects. In spite of abundant attention in the scientific literature, the mechanism of its prosocial effects has not been elucidated in humans. Recently, research in animals has suggested that the neuropeptide oxytocin may induce these effects. In a double blind, rand...