Bowman-Birk inhibitor is a protease inhibitor derived from soybeans that has demonstrated chemopreventive activity in a number of in vitro and animal systems. We conducted a 1-month phase IIa clinical trial of Bowman-Birk inhibitor concentrate (BBIC) in patients with oral leukoplakia. BBIC was administered to 32 subjects with oral leukoplakia for 1 month. We assessed toxicity and clinical and h...

The article studies the prevalence of dental diseases oral mucosa among adult population Kabardino-Balkarian Republic, Moscow and Vladimir regions; identification predictors malignancy. analysis 345 outpatient records a patient in 3 regions Russian Federation: region, Republic was carried out. It revealed that nosology’s first diagnosed patients with mucosa, leukoplakia prevailed all (15.2 %, 1...

Hansen et al. (1985) described proliferative verrucous leukoplakia (PVL) as a distinct entity of leukoplakia, presenting as verrucous, or exophytic lesion with progressive histological changes in sequential biopsies such as hyperkeratosis, different grades of dysplasia, verrucous carcinoma, and squamous cell carcinoma (SCC) [1]. In 2005, the WHO defined PVL as a rare subtype of oral leukoplakia...

The authors used multivariate repeated-measures transition models to identify risk factors for two oral lesions related to human immunodeficiency virus (HIV)-candidiasis and hairy leukoplakia-in 152 HIV-infected blood transfusion recipients and hemophiliacs. Subjects were examined for occurrences of these lesions every 6 months from July 1985 through March 1993, yielding 1,076 study visits. It ...

Oral leukoplakia (OL) is the most common potentially malignant disorder of the oral mucosa. The etiological role of Candida in leukoplakia has been a subject of debate in recent years. Candida invasion has been suggested to be a significant risk factor for malignant transformation of OL and also it may be associated with certain clinical characteristics such as lesion type, size, and site, dysp...

In immunocompromised subjects, Epstein-Barr virus (EBV) infection of terminally differentiated oral keratinocytes may result in subclinical productive infection of the virus in the stratum spinosum and in the stratum granulosum with shedding of infectious virions into the oral fluid in the desquamating cells. In a minority of cases this productive infection with dysregulation of the cell cycle ...

OBJECTIVE We aim to evaluate the effectiveness of the brush biopsy technique using OralCDx ® (OralScan Laboratories Inc., Suffern, NY) as a new method for early diagnosis and control of a "potentially malignant disorder" such as oral leukoplakia. DESIGN OF THE STUDY We performed a study in which samples were taken using OralCDx ® on 24 patients who visited the Master of Oral Medicine, Oral Su...