PURPOSE Smoking is a potent inducer of cytochrome P450 (CYP) 1A2 and may affect the pharmacokinetics of CYP1A2 metabolized drugs. The effect of smoking on the pharmacokinetics of imatinib, which is metabolized by CYP3A4 and partly by CYP1A2, is unknown. We studied the effect of smoking on imatinib pharmacokinetics, safety, and efficacy. EXPERIMENTAL DESIGN Imatinib pharmacokinetics, safety, a...

Primary synovial sarcoma of mediastinum is very rare among soft tissue sarcomas. Only a few cases have been reportedin the literatures. The best treatment is still unclear, but, surgical resection is the main therapy. In this article we reporta case of a 20*20 cm (2000gr) primary giant mediastinal synovial sarcoma in a 42 year-old man. We performed radicalexcision of the tumor...

Sotorasib, an oral small-molecule inhibitor, reportedly exerts promising activity against Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant tumors. However, the currently administered dose may fail to represent optimal based on therapeutic efficacy. Herein, we developed a simple and sensitive method using high-performance liquid chromatography with ultraviolet (HPLC-UV) measure sotorasib...

Kaposi's sarcoma (KS) remains the most common tumor arising in patients with HIV/AIDS, and involvement of the oral cavity represents one of the most common clinical manifestations of this tumor. HIV infection incurs an increased risk for periodontal diseases and oral carriage of a variety of bacteria. Whether interactions involving pathogenic bacteria and oncogenic viruses in the local environm...

Granulocytic Sarcoma (GS), an unusual extramedullary tumor, is composed of immature granulocytic precursor cells. The intraoral occurrence of this tumor is extremely rare. Here, we report a case of GS with palatal swelling, gingival lesions in maxilla and mandible and aleukemic presentation in a 45- year- old male.

This study was carried out to assess the use of HIV-related oral lesions as markers of immunosuppression defined as CD4+ cell counts <200 cells/mm and viral load 20,000 copies/ml in HIV positive Nigerian adults. Cross-sectional study on 278 HAART naive adults seen at an AIDS referral Centre.Oral examination was according to the European Community Clearinghouse on oral problems related to HIV in...

        Ewing's sarcoma is a relatively common malignant bone tumor that typically occurs in long bone diaphyses of adolescents and young adults of 10-30 years old. Often times, all Ewing's sarcoma of bone have radiographic abnormalities. Diagnosis is usually delayed and can be misdiagnosed as osteomyelitis. Bone to bone metastasis occurs, but soft tissue retro bulbar metastas...

radiation induced sarcoma is a rare but recognized complication of radiotherapy and is associated with poor prognosis, frequently occurs 5 years after completion of treatment. we report radiation-induced sarcoma in a 42 years old male, involving the left parietooccipital scalp region following treatment of brain tumor with craniotomy and post-operative radiation with 60co machine. diagnosis of ...

kaposi's sarcoma is a low-grade vascular tumor that its prevalence is increasing all around the world due to the increasing prevalence of hiv and organ transplantations. in this study, we assessed risk factors of kaposi's sarcoma among iranian patients were referred to dermatopathology department of razi hospital of tehran university of medical sciences between the years of 2006 to 2011. also, ...