Combined treatment with ketoconazole and luteinising hormone releasing hormone analogue: a novel approach to resistant progressive prostatic cancer Adenocarcinoma of the prostate is androgen dependent in 80°' of patients. Most circulating testosterone is secreted by the testes, but the adrenal glands contribute appreciably towards production of androgens. Conventional endocrine management is cu...

Case 1 A 24-year-old man presented with a 6-month history of pain and swelling of the right testis. Examination revealed a hard, irregular, enlarged testis and signs of a pleural effusion. Chest X-ray confirmed the effusion together with widespread secondary spread. A right orchidectomy was performed and the testis found to be replaced by a malignant trophoblastic teratoma. Post-operatively he ...

Giant leiomyosarcoma of scrotum is a rare tumour. A case of scrotum leiomyosarcoma is presented in a 67 year old patient with scrotal filariasis which was managed successfully with total scrotectomy with bilateral orchidectomy, degloved penis reconstructed with rotation advancement supra pubic fasciocutaneous flap. We made a literature search proving the rarity of this lesion type. Only 36 case...

In this paper, we evaluated the historical features and physical examination findings, as well as laboratory tests and ultrasound examinations, in children with testicular torsion (TT), in order to improve diagnosis and treatment in this population. A retrospective review of patients with diagnosis of TT between January 1990 and January 2010 was performed. We included 118 cases in the study, ac...

OBJECTIVES Simple intratesticular cysts are being reported more commonly due to the wider use of scrotal ultrasonography however, their management remains unclear. Treatment has included enucleation, radical orchidectomy (over fear of an associated malignancy) and a more conservative approach with serial ultrasonography (if a neoplastic cyst is clearly ruled out). In view of the benign nature o...

Introduction: Testicular torsion is a surgical emergency which requires early diagnosis and prompt surgical management to avoid testicular damage. The aim of this study is to survey the clinical findings and outcome of the patients treated for testicular torsion in a university hospital in Babol, northern Iran. Methods: In this cross sectional study, a retrospective survey of all cases presenti...

Testicular germ cell tumours (TGCT), including seminomas, embryonal carcinomas, teratomas and yolk sac tumours, have a common precursor, the carcinoma in situ (CIS) cell. Recent gene expression studies displaying close similarity of CIS cells to embryonic stem cells support the longstanding theory that CIS most likely originates in utero from fetal gonocytes. The clinical association between th...

OBJECTIVE To study the presentation, management and outcome of undescended testes in children in a northern Nigerian population. DESIGN Retrospective study. SETTING Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. SUBJECTS Thirty six children aged < or = 12 years with 43 undescended testes managed in 10 years. INTERVENTIONS Orchidopexy, orchidectomy, herniotomy. RESULTS The ...

BACKGROUND Solid tumor metastasis to the epididymis is a rare occurrence and is mostly discovered incidentally at autopsy or after therapeutic orchidectomy for prostate cancer. Other primary carcinomas that have been demonstrated to metastasize to the paratesticular region include those originating in the stomach, kidney, ileum, and colon. CASE PRESENTATION A 72-year-old gentleman presented w...

Objective: To report our experience of a contemporary series of patients who underwent radical orchidectomy for non-palpable testicular masses, in order to comment on their malignant potential and identify any factors predictive of a malignant outcome. Materials and Methods: We reviewed the case-notes of patients who underwent radical inguinal orchidectomy over a 22-month period between January...