Post-transplant complications such as graft-versus-host disease and graft ischemia-reperfusion injury are crucial challenges in transplantation. Hydrogen can act as a potential antioxidant, playing a preventive role against post-transplant complications in animal models of multiple organ transplantation. Herein, the authors review the current literature regarding the effects of hydrogen on graf...

To define the roles of endothelial-intrinsic nuclear factor kappaB (NF-kappaB) activity in host defense and multiple organ injury in response to sepsis, we generated double transgenic (TG) mice (EC-rtTA/I-kappaB alpha mt) that conditionally overexpress a degradation-resistant form of the NF-kappaB inhibitor I-kappaB alpha (I-kappaB alpha mt) selectively on vascular endothelium. The EC-rtTA/I-ka...

conclusions the loss of hrc at the onset of admission may predict mortality in patients with blunt trauma. lower entropy, in recently admitted patients with intra-abdominal bleeding, may indicate laparotomy when the vital signs are stable. background nonlinear analysis of heart rate variability (hrv) has been recently used as a predictor of prognosis in trauma patients. objectives we applied no...

conclusions it seems that fast examination for intra-abdominal fluid in blunt trauma patients can predict intra-abdominal injuries with very high sensitivity and specificity. using the scoring system can more accurately determine the probability of the presence of abdominal injuries with a cut-off point of three. results the mean age of the patients was 29.6 ± 18.3 years and fast was positive i...

spleen is the most frequently-injured solid organ in blunt abdominal trauma. considering its important role in providing immunity and preventing infection by a variety of mechanisms, every attempt should be made to salvage the traumatized spleen at any age particularly in children. after primary resuscitation, mandatory requirements for non-operative management include absence of homodynamic in...

cells are active components in their environment and constantly adjusting their performance to improve extracellular milieu changing. this approach is reflected their tends of maintaining intracellular homeostasis. when the cells encounter stress or pathologic stimuli, they can undergo a new manner (adaptation) and new steady state for achieving viability and function. if the external stress is...

Sepsis is considered today a major public health problem. Despite that mortality has been consistently associated with organ compromise, the mechanisms by which sepsis causes multiple organ dysfunction are not well understood, and hence, therapy remains reactive and non-specific. Recent studies have challenged previous paradigms by demonstrating that acute kidney injury can occur in the setting...

BACKGROUND Cell-free DNA concentrations increase in the circulation of patients after trauma and may have prognostic potential, but little is know concerning the temporal changes or clearance of the DNA or its relationships with posttraumatic complications. We investigated temporal changes in plasma DNA concentrations in patients after trauma with use of real-time quantitative PCR. METHODS Se...