Organic Synthesis is a computationally challenging practical problem concerned with constructing a target molecule from a set of initially available molecules via chemical reactions. This paper demonstrates how organic synthesis can be formulated as a planning problem in Artificial Intelligence, and how it can be explored using the state-of-the-art domain independent planners. To this end, we d...

amidoalkyl-2-naphthols as synthetic intermediates play an important role in medicinal chemistry due to their remarkable biological and many pharmacological properties. owing to the versatile biological activities, industrial and synthetic applications of these compounds, introduction of an alternative methodology is urgent in synthetic organic chemistry. low yield and harsh reaction conditions ...

Revolution in organic compound synthesis has been promoted by microwave assisted organic syntheses (MAOS) by which small molecules are built up into large polymers in a fraction of time. The need for different organic compound libraries for drug discovery, biomaterial development, automated library screening; proteomics etc has supported the emergence of innovative technologies for rapid combin...

Organic Synthesis, quo vadis?3 has been a phrase, perhaps in a more modern language, on the lips of the practitioners of this demanding science-art, undoubtedly from the earliest times4 but more vigorously in the last two decades.5 Comparison of achievements of yesterday6 and today7 suggests progress in our abilities to construct molecules of complexity, with higher stereocontrol, faster analys...

Continued on page 2 DNA is the blueprint of life because of its role as the genetic material, and it plays pivotal roles in molecular biology. DNA molecules not only carry genetic information, but also serve as templates to direct the synthesis of messenger RNA, the subsequent translation enable nature to produce its highly versatile functional macromolecules, proteins, which are considered the...

"LICKOR mixtures of organolithium reagents and bulky potassium alcoholates allow the smooth metalation and subsequent electrophilic substitution of low acidity hydrocarbons, in particular olefm. The allylpotassium intermediates exhibit peculiar conformational preferences which can be exploited in novel stereoselective carbon-carbon linking reactions. A few syntheses of simple natural products i...