SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent inhibition of β-(1,3)-d-glucan synthesis, an essential cell wall component of many pathogenic fungi, including Candida spp. and Aspergillus spp. SCY-078 is currently in phase 2 clinical development for the treatment of invasive ...

Candidaauris, a new multidrug-resistant Candida spp. which is associated with invasive infection and high rates of mortality, has recently emerged. Here, we determined the virulence factors (germination, adherence, biofilm formation, phospholipase and proteinase production) of 16 C. auris isolates and their susceptibilities to 11 drugs belonging to different antifungal classes, including a nove...

The literature on organizational culture is as relevant to public science management as it is to the management of private sector business organizations. Given a rapidly changing environment and continuing insights into organizational effectiveness, science organizations, as most other organizations, are seriously rethinking what they do and how they can best define and accomplish their goals a...

the main purpose of this study was to investigate the relationship between organizational culture and knowledge management in hamedan's jihad- agriculture applied-scientific higher education center (hjaas). denison's organizational culture model and the building blocks of knowledge management model were used for finding this relationship. a descriptive correlative methodology was used. the stat...

BACKGROUND The presence of indistinguishable strains of Clostridium difficile in humans, food animals and food, as well as the apparent emergence of the food-animal-associated ribotype 078/toxinotype V as a cause of community-associated C. difficile infection have created concerns about the potential for foodborne infection. While studies have reported C. difficile in calves, studies of cattle ...

organizational transparency has been considered by many experts in the past two decades. in the previous studies more attention has been taken to disclosure of the information; and the relations between the concepts of organizational transparency, organizational culture and performance has not been considered in this article as set forth. therefore, current research has been studied the effect ...

intreduction: nowadays, organizational eultcure plays an important role in the process of developing and reconstructing an organization. the selection of an appropriate leadership style by the manager has an significant impact on the development and establishment of a favorable oragnizational culture wich pares the ground for the organization to comete with others. metheds and materials: the is...

this study aims to consider the relationships between job fatigue, organizational citizenship behavior and organizational atmosphere. the evaluation of each variable is a kind of decision making problem which has systematic transaction between variables. so, decision making trial and evaluation laboratory (dematel) is suitable for defining the cause and effect relationships between variables. w...

We present a dynamic model of knowledge management in which knowledge sharing influences organizational culture. Employees’ fit with the organizational culture improves with the sharing and learning of common organizational practices. We analyze the impact of providing incentives for knowledge sharing as well as the investment of information technology in shaping knowledge sharing. Using analyt...

Organizational culture and occupational culture are powerful forces that drive organizations and their members. This study explores their effects on the perception of managerial accounting terms, as measured by semantic differential scales. The sample comprises two occupational groups (i.e. 64 management accountants and 68 non-financial managers) in ten organizations. Organizational culture is ...