The first of a new class spiroalkane-derived MOF linkers shows aromaticity is not prerequisite for ligand design in porous materials.

Inflation-linked bonds have gained notoriety in recent years. The global volume has increased tenfold in the past decade, with the United States, the United Kingdom, and France among the largest issuers of these securities. Inflation-linked bonds (commonly known as linkers) are a unique asset class in that it is one of the few that offers a nearly perfect (direct) hedge against inflation, while...

Antibody-drug conjugates (ADCs) have become a promising targeted therapy strategy that combines the specificity, favorable pharmacokinetics and biodistributions of antibodies with the destructive potential of highly potent drugs. One of the biggest challenges in the development of ADCs is the application of suitable linkers for conjugating drugs to antibodies. Recently, the design and synthesis...

The synthesis and NMR structural studies are reported for a modular threading tetraintercalator bound to DNA. The tetraintercalator design is based on 1,4,5,8-tetracarboxylic naphthalene diimide units connected through flexible peptide linkers. Aided by an overall C(2) symmetry, NMR analysis verified a threading polyintercalation mode of binding, with linkers alternating in the order minor groo...

Two non-interpenetrated zirconium metal-organic frameworks (Zr-MOFs), NPF-200 and NPF-201, were synthesized via the assembly of elongated tetrahedral linkers with Zr6 and Zr8 clusters. They represent the first examples of MOFs to have the β-UH3-like, 4,12,12T1 topology. Upon activation, NPF-200 exhibits the largest BET surface area (5463 m(2) g(-1)) and void volume (81.6%) among all MOFs formed...

Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload. Much success stems from the rational design of "toxic warheads", chemically linked to antibodies, and from fine-tuning the intricate properties of chemical linkers. Here...

An efficient and versatile non-destructive method to analyze the progress of solid-phase glycoconjugate synthesis with gel-phase F NMR spectroscopy is described. The method relies on use of fluorinated linkers and building blocks carrying fluorinated protective groups. Commercially available fluorinated reagents have been utilized to attach the protective groups. The influence of resin structur...

Despite remarkable progress in the field of MOFs, structures based on long-flexible organic linkers are scarce and the majority of such materials rely on rigid linkers. In this work, crystals of a new metal-organic double ladder (MODL) are obtained by linking a pentapeptide (NH2-Glu-pCO2Phe-pCO2Phe-Ala-Gly-OH) with cadmium acetate to produce a Cd(2-pyrrolidone-pCO2Phe-pCO2Phe-Ala-Gly)(H2O)3 fra...

This critical review covers the application of computer simulations, including quantum calculations (ab initio and DFT), grand canonical Monte-Carlo simulations, and molecular dynamics simulations, to the burgeoning area of the hydrogen storage by metal-organic frameworks and covalent-organic frameworks. This review begins with an overview of the theoretical methods obtained from previous studi...

Objective: This paper has the purpose to discuss how corporate networks’ big linkers constitute a development opportunity area in Latin America. Method: We employ qualitative analysis that blends social networks literature and builds on interlocking directorates (IntDs) theory with fascinating case study labeled ‘Patient 31’ phenomenon occurred during coronavirus outbreak South Korea. Main resu...