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The epidermal growth factor receptor (EGFR) regulates cell proliferation in many tissues. A new structure of the Drosophila EGFR presented by Alvarado et al. (2010) reveals an asymmetric dimer with the ligand bound to only one subunit. The structure provides a rationale for the receptor's negative cooperativity and necessitates a reconsideration of models for activation of human EGFR.
n engl j med 367;25 nejm.org december 20, 2012 2365 new front in the health care reform debate. By a seven-to-two margin, the justices found unduly coercive the government’s plan to withhold all federal Medicaid funds from states that don’t expand their Medicaid programs. Staking out a middle ground, the Court ruled that the ACA’s Medicaid expansion could go forward as an option for states. Alr...
BACKGROUND Prepared food sources, including fast food restaurants and carry-outs, are common in low-income urban areas. These establishments provide foods high in calories, sugar, fat, and sodium. The aims of the study were to (1) describe the development and implementation of a carry-out intervention to provide and promote healthy food choices in prepared food sources, and (2) to assess its fe...
The behavioral pattern of activity followed by rest (activity:rest) is an evolutionarily conserved trait. A prominent manifestation of rest in vertebrates consists of sleep, which is adaptive because a disruption of sleep by internal or external influences results in severe health outcomes such as obesity, mood disorders, cognitive impairment, and so forth. Despite the clinical imperative to un...
BACKGROUND The World Health Organization (WHO) early warning indicators (EWIs) of HIV drug resistance (HIVDR) assess factors at individual ART sites that are known to create situations favourable to the emergence of HIVDR. METHODS In 2014, the Namibia HIV care and treatment program abstracted the following adult and pediatric EWIs from all public ART sites (50 main sites and 143 outreach site...
BACKGROUND To better understand how stock-outs of the first line antimalarial, Artemisinin-based Combination Therapy (ACT) and other non-compliant health worker behaviour, influence household expenditures during care-seeking for fever in the Ulanga District in Tanzania. METHODS We combined weekly ACT stock data for the period 2009-2011 from six health facilities in the Ulanga District in Tanz...
Pharmacological studies suggest that dopamine release from lateral olivocochlear efferent neurons suppresses spontaneous and sound-evoked activity in cochlear nerve fibers and helps control noise-induced excitotoxicity; however, the literature on cochlear expression and localization of dopamine receptors is contradictory. To better characterize cochlear dopaminergic signaling, we studied recept...
OBJECTIVES To determine whether the items on the Time Out and the Sign Out of the Surgical Safety Checklist are properly checked by operating room (OR) staff and to explore whether the number of checked items is influenced by the severity of the intervention and the use of the checklist as a memory tool during the Time Out and the Sign Out periods. METHODS From March to July 2010, data were c...
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