With the cure rate for many pediatric malignancies now between 70% and 90%, infertility becomes an increasingly important issue. Strategies for preserving fertility in girls and adolescent women occur in two distinct phases. The first phase includes oophorectomy (usually unilateral) and cryopreservation of ovarian cortex slices or individual oocytes; ultrasound-guided needle aspiration of oocyt...

BACKGROUND Ovarian tissue cryopreservation is a promising technique to safeguard fertility in cancer patients. However, in some types of cancer, there is a risk of transmitting malignant cells present in the cryopreserved tissue. To avoid such a risk, pre-antral follicles could be isolated from ovarian tissue and grown in vitro. On the basis of this assumption, the aim of our study was to inves...

Fertility preservation has gained increased acceptance, and many reproductive medicine centers have established programs for this service. A recent report, which collected data from all Nordic university hospitals that had initiated programs for fertility preservation (N = 14), found that breast cancer is the most common diagnosis among women who underwent procedures aimed at fertility preserva...

t d t d b SUMMARY 1. Physicians should inform cancer patients about options for fertility preservation and future reproduction prior to treatment. 2. The only established methods of fertility preservation are sperm cryopreservation in men and embryo cryopreservation in women. 3. Experimental procedures such as oocyte or ovarian tissue cryopreservation should be offered only in a research settin...

t d t d b SUMMARY 1. Physicians should inform cancer patients about options for fertility preservation and future reproduction prior to treatment. 2. The only established methods of fertility preservation are sperm cryopreservation in men and embryo cryopreservation in women. 3. Experimental procedures such as oocyte or ovarian tissue cryopreservation should be offered only in a research settin...

Background The conventional freezing and vitrification are different cryopreservation protocols for fertility preservation in cancer patients. The high effectiveness of vitrification for human oocytes and embryos is shown, whereas data on human ovarian tissue are limited. Follicular growth, ultrastructure, and apoptosis incidence in human ovarian tissue following vitrification/warming and after...

BACKGROUND Cancer treatments, including chemotherapy, radiotherapy, and radical surgery, can induce premature menopause and infertility in hundreds of thousands of women of reproductive age every year. One of the ways to possibly preserve fertility before these treatments is to cryopreserve ovarian tissue for later transplantation. We aimed to restore fertility by cryopreservation and transplan...