PURPOSE Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian tumors partly derive from endometriosis, a commonly diagnosed chronic inflammatory disease. We performed here a comprehensive immune gene expression analysis of pelvi...

BACKGROUND To assess the feasibility of texture analysis (TA) based on spectral attenuated inversion-recovery T2 weighted magnetic resonance imaging (SPAIR T2W-MRI) for the classification of hepatic hemangioma (HH), hepatic metastases (HM) and hepatocellular carcinoma (HCC). METHODS The SPAIR T2W-MRI data of 162 patients with HH (n=55), HM (n=67) and HCC (n=40) were retrospectively analyzed. ...

Objective: To determine the efficacy of ovarian drilling in PCO patients who failed to achieve pregnancy with medical treatment. Methods and Main Results: 75 patients with a diagnosis of PCO of whom 48(64%) were primary infertile and 27(36%) were secondary infertile were clomiphene resistant. The other methods like bromocriptin, gonadotropins, GnRH -a and metformin had been given to these ...

Endometriosis is defined as presence of endometrial tissue outside of the uterus. It is a common disorder of women in reproductive age. It is estimated to occur in ten percent iof women in this age and even more in patients with infertility and pelvic pain. Endometriosis varies in appearance from a few minimal lesions to massive ovarian endometriotic cysts that distort the tubo-ovarian anatomy ...

INTRODUCTION Intraoperative fluorescence imaging of the folate-receptor alpha (FRα) could support completeness of resection in cancer surgery. Feasibility of EC17, a FRα-targeting agent that fluoresces at 500nm, was demonstrated in a limited series of ovarian cancer patients. Our objective was to evaluate EC17 in a larger group of ovarian cancer patients. In addition, we assessed the feasibilit...

background: gingival involvement is commonly seen in lichen planus, a chronic mucocutaneous infl ammatory condition of the stratifi ed squamous epithelia. it is often painful and may undergo malignant transformation and thus warrants early diagnosis and prompt treatment. the aim of this study is to evaluate the use of a bioresorbable membrane (polyglactin 910) in the management of erosive liche...

OBJECTIVE In ovarian cancer, two of the most important prognostic factors for survival are completeness of staging and completeness of cytoreductive surgery. Therefore, intra-operative visualization of tumor lesions is of great importance. Preclinical data already demonstrated tumor visualization in a mouse-model using near-infrared (NIR) fluorescence imaging and indocyanine green (ICG) as a re...

OBJECTIVE To evaluate the correlation between microembolism (ME) and incidence of silent brain infarcts during carotid endarterectomy. MATERIALS AND METHODS Patients were assessed using transcranial Doppler, carotid ultrasound and pre- and postoperative magnetic resonance imaging (MRIs). The clinical status, need for shunt insertion and significant decrease in the blood flow in the middle cer...