Several distinct congenital disorders can lead to tissue-iron overload with anemia. Repeated blood transfusions are one of the major causes of iron overload in several of these disorders, including β-thalassemia major, which is characterized by a defective β-globin gene. In this state, hyperabsorption of iron is also observed and can significantly contribute to iron overload. In β-thalassemia i...

The recent technological advancement has proved to be tremendously helpful for medical consultants. However, this advancement has also generated an enormous volume and variety of data, with a high velocity causing an information load for the medical consultants. Information overload can be defined as a difficulty a person can have in comprehending issue and making judgments that are caused by t...

This paper describes a runtime scheduling method for a mix of off-line scheduled and value based dynamic tasks with a focus on overload situations. We present a formulation of overload handling as a general binary optimisation problem and give an algorithm for solving it. Our method is based on slot shifting [4] to provide for the integration of offline and online scheduling. Dynamic tasks are ...

This study's purpose was to examine whether functional overload with nandrolone decanoate (ND) administration increased muscle mass and steroid receptor concentration in aged rat soleus (Sol) and plantaris (Plan) muscle. ND (6 mg/kg body wt) was administered once a week for 4 wk, whereas control rats received sesame seed oil injections. Functional overload of the hindlimb Sol and Plan was induc...

Petrak, Jiri, Denisa Myslivcova, Petr Man, Radek Cmejla, Jana Cmejlova, and Daniel Vyoral. Proteomic analysis of iron overload in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol 290:G1059–G1066, 2006. First published January 12, 2006; doi:10.1152/ajpgi.00469.2005.—Iron-mediated organ damage is common in patients with iron overload diseases, namely, hereditary hemochromatosis. Mass...

Although many animal studies indicate insulin has cardioprotective effects, clinical studies suggest a link between insulin resistance (hyperinsulinemia) and heart failure (HF). Here we have demonstrated that excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. Chronic pressure overload induced hepatic insulin resistance and plasma insuli...

Last year’s trend to migrate circuit-switched voice networks to packet switched Internet Protocol (IP) based networks has favored wide deployment of Session Initiation Protocol (SIP) based systems and networks. As a reaction to large-scale SIP deployment experiences in the field and the need to implement high availability and reliability within these new networks, the focus of SIP extension sta...

To characterize responses of the left ventricle (LV) to pressure overload at the genomic level, we performed high-density microarray analysis on individual mouse LVs. Male and female mice underwent transverse aortic constriction. At 1 day and 30 wk, the LV free wall was harvested and RNA isolated from 27 individual ventricles was analyzed on Mu74Av2 GeneChips, which contain approximately 12,483...

Background: Iron overload is caused early progression of atherosclerosis in beta thalassemia patients due to regular repeated blood transfusion. MRI T2* is a gold standard non-invasive method for detecting hepatic and cardiac iron overload. The aim of this study was the comparison of carotid intima media thickness (CIMT) in the patients and healthy control groups with Doppler ultrasound for ear...

Objective: To aims determine the level of compliance with workload, work-related strain and isolation measures as well effect work overload in physicians nurses working a state hospital throughout COVID-19 pandemic. Material Methods: The study was conducted descriptive design. data were obtained from 91 386 (n=477) public Istanbul between November 2020 February 2021 who volunteered to participa...