نتایج جستجو برای: oxazolone
تعداد نتایج: 441 فیلتر نتایج به سال:
Abstract Contact hypersensitivity (CHS) is an experimental model of human allergic contact dermatitis, one the representative skin diseases, where NLRP3 inflammasome plays a crucial role. Although regulation activity by cannabinoid 1 receptor (CB1R) has been shown in metabolic diseases such as obesity and type 2 diabetes, role CB1R CHS unclear. Here, we investigate putative using selective anta...
The role of CD4(+) vs CD8(+) T cells in contact hypersensitivity (CHS) remains controversial. In this study, we used gene knockout (KO) mice deficient in CD4(+) or CD8(+) T cells to directly address this issue. Mice lacking either CD4(+) or CD8(+) T cells demonstrated depressed CHS responses to dinitrofluorobenzene and oxazolone compared with wild-type C57BL/6 mice. The depression of CHS was mo...
In this research work, 2, 4-substituted oxazolone derivatives OXZ-1 to OXZ-5 were screened for antidiabetic activity at 200 and 400 mg/kg b.w. p.o. for 15 days in streptozotocin induced diabetic rats. Acute and sub-acute toxicity studies were performed as per OECD guideline Up and Down Procedure425 and 407. Clinical signs, body weight, hematological, biochemical and histopathological examinatio...
Oxazolone-induced gastrointestinal disorders enhance the oral transmission of AA amyloidosis in mice
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