AIM Excess levels of free radicals such as nitric oxide (NO) and superoxide anion (O(2)(-)) are associated with the pathogenesis of endothelial cell dysfunction in diabetes mellitus. This study was designed to investigate the underlying causes of oxidative stress in coronary microvascular endothelial cells (CMECs) exposed to hyperglycaemia. METHODS CMECs were cultured under normal (5.5 mmol/l...

Smoking is a major risk factor in COPD [Chronic Obstructive Pulmonary Disease]. It contributes to inflammation and oxidative stress which are implicated in hyperlipidemia and lung function decline. Exercise may result in anti-inflammatory effects which limit smoking induced changes in COPD. The aim of the present study was to evaluate the oxidant antioxidant imbalance and lipid profile in exerc...

Background: To attain whether the effects of low and high doses of estrogen, progesterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) in acute and chronic administration were related to oxidant and antioxidant parameters in rat uterine tissue as well as cyclooxygenase-1 (COX-1) activity. Materials and Methods: Acute and chronic administration of estrogen (1 and 5 mg/ kg), ...

Several recent hypotheses consider oxidative stress to be a primary constraint ensuring honesty of condition-dependent carotenoid-based signalling. The key testable difference between these hypotheses is the assumed importance of carotenoids for redox homeostasis, with carotenoids being either antioxidant, pro-oxidant or unimportant. We tested the role of carotenoids in redox balance and sexual...

BACKGROUND Oxidative stress may be involved in the pathogenesis of every human disease. To understand its possible role in benign prostatic hyperplasia (BPH), we measured the overall oxidative status of patients with BPH and the serum activity of the high density lipoprotein (HDL)-related antioxidant enzymes paraoxonase 1 (PON1) and arylesterase (ARE). METHODS Fifty-six urology outpatient cli...

Laryngeal tumours with multifactorial etiopathogenesis constitute ∼1% of all body cancers. The imbalance between oxidative and antioxidative systems affects redox-homeostasis. stress generated by the continuous formation reactive oxygen species results in oxidation cellular molecules. present study investigated protein levels distribution receptors for advanced glycation end products (RAGE) var...

abstract background and objective: diabetes mellitus is associated with cardiomyopathic changes, can be mediated by an oxidative stress. we aimed to study the effects of regular aerobic training and arbutin supplementation on total oxidant status (tos) and total antioxidant (tas) status in the cardiac tissue of diabetic rats. material and methods: fourty-two male wistar rats with an average wei...

Reactive oxidant species (ROS), products of normal metabolism, cause oxidant injury if they accumulate in pathological amounts. Lysozyme (LZ) contains an 18-amino acid domain that binds agents such as advanced glycation end products (AGE) that generate ROS. We examined whether endogenous LZ affected physiological, or baseline, antioxidant balance and provided protection against both acute and c...

This study entailed a cross-examination of oxidant/antioxidant balance, high-density lipoprotein (HDL)-linked paraoxonase 1 (PON1) phenotypes, and levels of serum routine lipids among patients with normal tension glaucoma (NTG) or pseudoexfoliative glaucoma (PEXG) compared with healthy control groups. We aimed to investigate the links between oxidative stress (OS), HDL-related antioxidant enzym...