The vascular endothelium compensates for oxidant stress by increasing the activity of antioxidant enzymes such as glucose-6-phophate dehydrogenase (G6PD). G6PD provides reducing equivalents of NAPDH to maintain glutathione stores and modulates nitric oxide synthase (eNOS) activity. To determine whether deficient G6PD activity perturbs these responses, we treated bovine aortic endothelial cells ...

Smoking is a major risk factor in COPD [Chronic Obstructive Pulmonary Disease]. It contributes to inflammation and oxidative stress which are implicated in hyperlipidemia and lung function decline. Exercise may result in anti-inflammatory effects which limit smoking induced changes in COPD. The aim of the present study was to evaluate the oxidant antioxidant imbalance and lipid profile in exerc...

BACKGROUND & OBJECTIVES Contrast media may cause contrast-induced nephropathy (CIN) in risk group. This study was taken up to establish possible effects of non ionic low osmolar contrast medium administration on oxidant/antioxidant status and nitric oxide (NO) levels in rat kidney tissues. METHODS Fourteen female, 14 wk old Wistar-albino rats were divided into 2 groups of 7 rats each (control...

This study was designed to determine the sequence of events leading to cardiopulmonary effects following acute inhalation of diesel engine exhaust in rats. Rats were exposed for 2 h to diesel engine exhaust (1.9 mg/m(3)), and biological parameters related to antioxidant defense, inflammation, and procoagulation were examined after 4, 18, 24, 48, and 72 h. This in vivo inhalation study showed a ...

Aim. To investigate the effects of static magnetic field (SMF) on oxidant and antioxidant parameters of the cancerous and noncancerous human gastric tissues. Materials and Methods. Gastric tissues obtained from patients with gastric cancer were used in the study. SMF was created by using two static magnets. Before and after treatment with SMF, oxidant and antioxidant parameters were measured in...

Data provided by WHO show that the prevalence of aggressive periodontitis is observed in almost 19% adult world population and associated with destruction attachment apparatus premature tooth loss. Development a periodontal pocket foci infection also negatively affect body on whole. Despite great number researches this field dramatic improvement treatment prophylaxis, problem high diseases rema...

Plantago laceolata considered as an ancient herb promising plant. In this work, the target of study was designed to estimate total flavonoids, anti-oxidant and chemical composition aqueous extract in vitro. Total flavonoids content was;evaluated extract, it 317.0000 ± 9.64365mg /ml. also, activity vitro assessed via evaluation reductive ability. At all concentrations plant tested (0.02, 0.04, 0...

High intake of fruit and vegetables is believed to be beneficial to human health. Fruit, vegetables and some beverages, such as tea and coffee, are particularly rich in dietary polyphenols. Various studies have suggested (but not proven) that dietary polyphenols may protect against cardiovasucalar diseases, neurodegenerative diseases and some forms of cancer. Dietary polyphenols may exert their...

The reduced nicotinamide adenine dinucleotide phosphate (NADPH) is pivotal to the cellular anti-oxidative defence strategies in most organisms. Although its production mediated by different enzyme systems has been relatively well-studied, metabolic networks dedicated to the biogenesis of NADPH have not been fully characterized. In this report, a metabolic pathway that promotes the conversion of...

Severe sepsis and septic shock are frequent causes of the acute respiratory distress syndrome, and important sources of human mortality. Lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls, plays a major role in the pathogenesis of severe sepsis and septic shock. LPS exposure induces the production of harmful reactive oxygen species, and the resultant oxidant injury has ...