An enantioselective oxa-Michael addition of oximes to β-CF3-β-disubstituted nitroalkenes catalyzed by a chiral bifunctional cinchona alkaloid-based thiourea has been developed. A variety of trifluoromethylated oxime ethers possessing a tetrasubstituted carbon stereocenter were obtained in good yields with high enantioselectivities.

An efficient copper-catalyzed method for N-arylation of amines has been developed with part-per-million catalyst loadings at room temperature under air. Reactions of substituted (E)-1-(2-halophenyl)alkanone oximes with aliphatic amines or aromatic amines provided the N-arylation products in good to excellent yields.

Oximes (with or without atropine as an adjunct) have recently been used successfully in the treatment of humans poisoned by organophosphate anticholinesterases. The discovery of the nature of the biochemical lesion in organophosphate poisoning has permitted the design of drugs to repair specifically this particular lesion. This paper reviews historically the researches which led to the developm...

' Nine of the subject compounds have been synalog, 2,2-dimethyl-3-thiophanone 0-(methylcarthesized and evaluated for their insecticidal bamoyl)oxime, elicits a miticidal response; this properties. These materials are characterized by material is also toxic to the aphid and housefly good activity to the housefly, a lower order of efand shows a high order of systemic activity. In fectiveness agai...

Organophoshorous poisoning is a common cause of death in developing countries. These compounds inhibit acetylcholinesterase leading to accumulation acetylcholine, causing overstimulation nicotinic and muscarinic receptors. Atropine oximes are the mainstay treatment. helps countering effects decreasing secretions. It also makes secretions thick, tenacious may obstruct airway. We observed five ca...

Metal-mediated secondary structures of peptide-based foldamers were constructed using artificial backbone-coordinative oxime peptides. Complexation of the peptides with Pd(II) afforded several mononuclear and dinuclear secondary structures such as helices and hairpins as confirmed by single-crystal XRD and NMR analyses.

A novel colorimetric probe for the selective and sensitive detection of NO2 in solution and in air based on a BODIPY core containing an oxime group has been prepared.

The title compound, C10H9NO2, is almost planar (r.m.s. deviation for the non-H atoms = 0.027 Å) and the conformation across the C=N bond is syn. Further, the O atom of the benzo-furan ring is syn to the CH3 group in the side chain. In the crystal, mol-ecules are linked into C(3) chains propagating in [010] by O-H⋯N hydrogen bonds.

A convenient method to prepare supramolecular bioconjugates in a facile and scalable manner is by a modular approach, whereby self-assembling units and peptides are coupled using oxime chemistry. We here report syntheses of bioactive ureidopyrimidinone-based peptide conjugates, and their resultant self-assembly into fibrous structures.