The inner parts of the arterial wall depend upon diffusion for nutrition and oxygenation. During the atherosclerotic process, increased intimal thickness leads to impaired diffusion, and at the same time the oxygen requirements increase. On this basis it has been suggested that the balance between the supply and demand of oxygen in the arterial wall may be important for the fate of the initiate...

The early postoperative hemodynamic data of 88 patients who underwent primary liver transplantation between July 1989 and October 1990 at the University Health Center of Pittsburgh were analyzed to establish the relationship of systemic hemodynamics and oxygen consumption to perioperative allograft function. The 15 patients whose allografts failed within the 1st month following transplantation ...

Neither stroke volume nor external cardiac work (the integral of pressure times flow during ejection) has been considered an important correlate of myocardial oxygen consumption. An initial set of experiments re-examined this question of independently varying heart rate, systolic blood pressure, and stroke volume in seven closed-chest, anesthetized dogs. This was achieved by cardiac pacing, a p...

Coronary blood flow responds uniquely to changes in myocardial demand, regardless of the stimulus. If adenosine mediates this response, interstitial fluid adenosine concentration should also change in parallel with myocardial oxygen consumption and coronary blood flow during alterations of cardiac work. We tested this hypothesis by measuring coronary blood flow, myocardial oxygen consumption, a...

Insufficient oxygen leads to the cessation of growth in favor of cellular survival. Our unique model of high-altitude human pregnancy indicates that hypoxia-induced reductions in fetal growth occur at higher levels of oxygen than previously described. Fetal PO(2) is surprisingly high and fetal oxygen consumption unaffected by high altitude, whereas fetal glucose delivery and consumption decreas...

l. Oxygen consumption, ventilation frequency and tidal volume were measured simultaneously in two lizards, Varanus gouldii and Sauromalus hispidus, during rest and maximal activity. 2. Ventilation frequency and tidal volume are almost identical in these species. The greater oxygen consumption during activity of Vat-anus results from a greater oxygen extraction from ventilated air. 3. Increased ...

The aim of this study was to determine which PGE2 receptors and signal transduction pathways are responsible for the stimulation of oxygen uptake in liver. Hepatic parenchymal cells isolated from female Sprague-Dawley rats were incubated either with PGE2, 17-phenyl-omega-trinor PGE2 (an EP1-specific agonist), or 11-deoxy PGE1 (an EP2/EP4-specific agonist), and oxygen consumption was measured. B...

Qu, Wei, Lee M. Graves, and Ronald G. Thurman. PGE2 stimulates O2 uptake in hepatic parenchymal cells: involvement of the cAMP-dependent protein kinase. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G1048–G1054, 1999.—The aim of this study was to determine which PGE2 receptors and signal transduction pathways are responsible for the stimulation of oxygen uptake in liver. Hepatic parenc...